Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pöykkö, S. M.
Right arrow Articles by Ukkola, O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pöykkö, S. M.
Right arrow Articles by Ukkola, O.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes 52:2546-2553, 2003
© 2003 by the American Diabetes Association, Inc.

Low Plasma Ghrelin Is Associated With Insulin Resistance, Hypertension, and the Prevalence of Type 2 Diabetes

Seppo M. Pöykkö, Eija Kellokoski, Sohvi Hörkkö, Heikki Kauma, Y. Antero Kesäniemi, and Olavi Ukkola

From the Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland

Experimental studies have suggested that ghrelin plays a role in glucose homeostasis and in the regulation of blood pressure (BP). We therefore assessed the hypothesis that a low ghrelin concentration may be a risk factor for type 2 diabetes and hypertension. We also characterized the effect of the ghrelin Arg51Gln and Leu72Met mutations on ghrelin concentrations in the population-based hypertensive (n = 519) and control (n = 526) cohorts of our OPERA (Oulu Project Elucidating Risk of Atherosclerosis) study. The fasting plasma ghrelin concentrations of 1,040 subjects were analyzed using the radioimmunoassay method. Insulin sensitivity was assessed using the quantitative insulin sensitivity check index (QUICKI). Ghrelin concentrations were negatively associated with fasting insulin (P < 0.001), systolic (P = 0.026) and diastolic BP (P = 0.018), and the prevalence of type 2 diabetes (P = 0.015) and insulin resistance (P < 0.001) in the multivariate models. In the control cohort, low ghrelin was associated with hypertension (BP >140/90 mmHg) (P = 0.031). The subjects with the ghrelin 51Gln allele had lower ghrelin concentrations than the Arg51Arg homozygotes (P = 0.001). We conclude that low ghrelin is independently associated with type 2 diabetes, insulin concentration, insulin resistance, and elevated BP. Therefore, it might have some role in the etiology of type 2 diabetes and the regulation of BP. The ghrelin Arg51Gln mutation is associated with low plasma ghrelin concentrations.

Address correspondence and reprint requests to Seppo Pöykkö, Laboratory of Internal Medicine, University of Oulu, P.O. Box 5000, FIN-90014 Oulu, Finland. E-mail: seppo.poykko{at}ppshp.fi


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
K. Wang, L. Wang, Y. Zhao, Y. Shi, L. Wang, and Z.-J. Chen
No association of the Arg51Gln and Leu72Met polymorphisms of the ghrelin gene and polycystic ovary syndrome
Hum. Reprod., December 1, 2008; (2008) den430v1.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. P. Cummings, E. K. Digitale, K. L. Stanhope, J. L. Graham, D. G. Baskin, B. J. Reed, I. R. Sweet, S. C. Griffen, and P. J. Havel
Development and characterization of a novel rat model of type 2 diabetes mellitus: the UC Davis type 2 diabetes mellitus UCD-T2DM rat
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2008; 295(6): R1782 - R1793.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. Ingelsson, M. G. Larson, X. Yin, T. J. Wang, J. B. Meigs, I. Lipinska, E. J. Benjamin, J. F. Keaney Jr., and R. S. Vasan
Circulating Ghrelin, Leptin, and Soluble Leptin Receptor Concentrations and Cardiometabolic Risk Factors in a Community-Based Sample
J. Clin. Endocrinol. Metab., August 1, 2008; 93(8): 3149 - 3157.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
X. Xu, B. Sook Jhun, C. Hoon Ha, and Z.-G. Jin
Molecular Mechanisms of Ghrelin-Mediated Endothelial Nitric Oxide Synthase Activation
Endocrinology, August 1, 2008; 149(8): 4183 - 4192.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
U. Mager, M. Kolehmainen, V. D F de Mello, U. Schwab, D. E Laaksonen, R. Rauramaa, H. Gylling, M. Atalay, L. Pulkkinen, and M. Uusitupa
Expression of ghrelin gene in peripheral blood mononuclear cells and plasma ghrelin concentrations in patients with metabolic syndrome.
Eur. J. Endocrinol., April 1, 2008; 158(4): 499 - 510.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Anderwald-Stadler, M. Krebs, M. Promintzer, M. Mandl, M. G. Bischof, P. Nowotny, T. Kastenbauer, A. Luger, R. Prager, and C. Anderwald
Plasma obestatin is lower at fasting and not suppressed by insulin in insulin-resistant humans
Am J Physiol Endocrinol Metab, November 1, 2007; 293(5): E1393 - E1398.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. Barazzoni, M. Zanetti, C. Ferreira, P. Vinci, A. Pirulli, M. Mucci, F. Dore, M. Fonda, B. Ciocchi, L. Cattin, et al.
Relationships between Desacylated and Acylated Ghrelin and Insulin Sensitivity in the Metabolic Syndrome
J. Clin. Endocrinol. Metab., October 1, 2007; 92(10): 3935 - 3940.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
K. Dezaki, M. Kakei, and T. Yada
Ghrelin Uses G{alpha}i2 and Activates Voltage-Dependent K+ Channels to Attenuate Glucose-Induced Ca2+ Signaling and Insulin Release in Islet {beta}-Cells: Novel Signal Transduction of Ghrelin
Diabetes, September 1, 2007; 56(9): 2319 - 2327.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
H. Iwakura, T. Akamizu, H. Ariyasu, T. Irako, K. Hosoda, K. Nakao, and K. Kangawa
Effects of ghrelin administration on decreased growth hormone status in obese animals
Am J Physiol Endocrinol Metab, September 1, 2007; 293(3): E819 - E825.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
R. Muniyappa, M. Montagnani, K. K. Koh, and M. J. Quon
Cardiovascular Actions of Insulin
Endocr. Rev., August 1, 2007; 28(5): 463 - 491.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. Rauh, M. Groschl, and W. Rascher
Simultaneous Quantification of Ghrelin and Desacyl-Ghrelin by Liquid Chromatography-Tandem Mass Spectrometry in Plasma, Serum, and Cell Supernatants
Clin. Chem., May 1, 2007; 53(5): 902 - 910.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
A. Baessler, M. Fischer, B. Mayer, M. Koehler, S. Wiedmann, K. Stark, A. Doering, J. Erdmann, G. Riegger, H. Schunkert, et al.
Epistatic interaction between haplotypes of the ghrelin ligand and receptor genes influence susceptibility to myocardial infarction and coronary artery disease
Hum. Mol. Genet., April 15, 2007; 16(8): 887 - 899.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Iantorno, H. Chen, J.-a Kim, M. Tesauro, D. Lauro, C. Cardillo, and M. J. Quon
Ghrelin has novel vascular actions that mimic PI 3-kinase-dependent actions of insulin to stimulate production of NO from endothelial cells
Am J Physiol Endocrinol Metab, March 1, 2007; 292(3): E756 - E764.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
A Majuri, M Santaniemi, K Rautio, A Kunnari, J Vartiainen, A Ruokonen, Y A Kesaniemi, J S Tapanainen, O Ukkola, and L Morin-Papunen
Rosiglitazone treatment increases plasma levels of adiponectin and decreases levels of resistin in overweight women with PCOS: a randomized placebo-controlled study
Eur. J. Endocrinol., February 1, 2007; 156(2): 263 - 269.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
C.-C. Chang, C.-H. Hung, H.-L. Chen, K.-L. Hwang, and C.-Y. Lin
Peritoneal transport characteristics and dwelling time significantly impact ghrelin clearance in peritoneal dialysis patients
Nephrol. Dial. Transplant., January 1, 2007; 22(1): 224 - 228.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
K. Dezaki, H. Sone, M. Koizumi, M. Nakata, M. Kakei, H. Nagai, H. Hosoda, K. Kangawa, and T. Yada
Blockade of Pancreatic Islet-Derived Ghrelin Enhances Insulin Secretion to Prevent High-Fat Diet-Induced Glucose Intolerance
Diabetes, December 1, 2006; 55(12): 3486 - 3493.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
H. J. Choi, Y. M. Cho, M. K. Moon, H. H. Choi, H. D. Shin, H. C. Jang, S. Y. Kim, H. K. Lee, and K. S. Park
Polymorphisms in the Ghrelin Gene Are Associated with Serum High-Density Lipoprotein Cholesterol Level and not with Type 2 Diabetes Mellitus in Koreans
J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4657 - 4663.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. Marzullo, A. Caumo, G. Savia, B. Verti, G. E. Walker, S. Maestrini, A. Tagliaferri, A. M. Di Blasio, and A. Liuzzi
Predictors of Postabsorptive Ghrelin Secretion after Intake of Different Macronutrients
J. Clin. Endocrinol. Metab., October 1, 2006; 91(10): 4124 - 4130.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
D. Glintborg, M. Andersen, C. Hagen, J. Frystyk, V. Hulstrom, A. Flyvbjerg, and A. P. Hermann
Evaluation of metabolic risk markers in polycystic ovary syndrome (PCOS). Adiponectin, ghrelin, leptin and body composition in hirsute PCOS patients and controls.
Eur. J. Endocrinol., August 1, 2006; 155(2): 337 - 345.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
D.-Y. Lee, S.-Y. Kim, D.-S. Jo, P. H. Hwang, K. P. Kang, S. Lee, W. Kim, and S. K. Park
Preproghrelin Leu72Met polymorphism predicts a lower rate of developing renal dysfunction in type 2 diabetic nephropathy.
Eur. J. Endocrinol., July 1, 2006; 155(1): 187 - 190.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. S. Damjanovic, N. M. Lalic, P. M. Pesko, M. S. Petakov, A. Jotic, D. Miljic, K. S. Lalic, L. Lukic, M. Djurovic, and V. B. Djukic
Acute Effects of Ghrelin on Insulin Secretion and Glucose Disposal Rate in Gastrectomized Patients
J. Clin. Endocrinol. Metab., July 1, 2006; 91(7): 2574 - 2581.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
C. Langenberg, J. Bergstrom, C. Scheidt-Nave, J. Pfeilschifter, and E. Barrett-Connor
Cardiovascular Death and the Metabolic Syndrome: Role of adiposity-signaling hormones and inflammatory markers.
Diabetes Care, June 1, 2006; 29(6): 1363 - 1369.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
T Akamizu, T Murayama, S Teramukai, K Miura, I Bando, T Irako, H Iwakura, H Ariyasu, H Hosoda, H Tada, et al.
Plasma ghrelin levels in healthy elderly volunteers: the levels of acylated ghrelin in elderly females correlate positively with serum IGF-I levels and bowel movement frequency and negatively with systolic blood pressure
J. Endocrinol., February 1, 2006; 188(2): 333 - 344.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
M. J. Kleinz, J. J. Maguire, J. N. Skepper, and A. P. Davenport
Functional and immunocytochemical evidence for a role of ghrelin and des-octanoyl ghrelin in the regulation of vascular tone in man
Cardiovasc Res, January 1, 2006; 69(1): 227 - 235.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. Langenberg, J. Bergstrom, G. A. Laughlin, and E. Barrett-Connor
Ghrelin and the Metabolic Syndrome in Older Adults
J. Clin. Endocrinol. Metab., December 1, 2005; 90(12): 6448 - 6453.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
N. I. Steinle, T. I. Pollin, J. R. O'Connell, B. D. Mitchell, and A. R. Shuldiner
Variants in the Ghrelin Gene Are Associated with Metabolic Syndrome in the Old Order Amish
J. Clin. Endocrinol. Metab., December 1, 2005; 90(12): 6672 - 6677.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. Tesauro, F. Schinzari, M. Iantorno, S. Rizza, D. Melina, D. Lauro, and C. Cardillo
Ghrelin Improves Endothelial Function in Patients With Metabolic Syndrome
Circulation, November 8, 2005; 112(19): 2986 - 2992.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
R. Giordano, A. Picu, U. Pagotto, R. De Iasio, L. Bonelli, F. Prodam, F. Broglio, L. Marafetti, R. Pasquali, M. Maccario, et al.
The negative association between total ghrelin levels, body mass and insulin secretion is lost in hypercortisolemic patients with Cushing's disease
Eur. J. Endocrinol., October 1, 2005; 153(4): 535 - 543.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
E T Vestergaard, T K Hansen, S Nielsen, N Moller, J S Christiansen, and J O L Jorgensen
Effects of GH replacement therapy in adults on serum levels of leptin and ghrelin: the role of lipolysis
Eur. J. Endocrinol., October 1, 2005; 153(4): 545 - 549.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
M. Suematsu, A. Katsuki, Y. Sumida, E. C Gabazza, S. Murashima, K. Matsumoto, N. Kitagawa, H. Akatsuka, Y. Hori, K. Nakatani, et al.
Decreased circulating levels of active ghrelin are associated with increased oxidative stress in obese subjects
Eur. J. Endocrinol., September 1, 2005; 153(3): 403 - 407.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L. J. Moran, N. D. Luscombe-Marsh, M. Noakes, G. A. Wittert, J. B. Keogh, and P. M. Clifton
The Satiating Effect of Dietary Protein Is Unrelated to Postprandial Ghrelin Secretion
J. Clin. Endocrinol. Metab., September 1, 2005; 90(9): 5205 - 5211.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. Kellokoski, S. M. Poykko, A. H. Karjalainen, O. Ukkola, J. Heikkinen, Y. A. Kesaniemi, and S. Horkko
Estrogen Replacement Therapy Increases Plasma Ghrelin Levels
J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2954 - 2963.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. Bacha and S. A. Arslanian
Ghrelin Suppression in Overweight Children: A Manifestation of Insulin Resistance?
J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2725 - 2730.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
W. A. Blom, A. Stafleu, C. de Graaf, F. J Kok, G. Schaafsma, and H. F. Hendriks
Ghrelin response to carbohydrate-enriched breakfast is related to insulin
Am. J. Clinical Nutrition, February 1, 2005; 81(2): 367 - 375.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. Korner, M. Bessler, L. J. Cirilo, I. M. Conwell, A. Daud, N. L. Restuccia, and S. L. Wardlaw
Effects of Roux-en-Y Gastric Bypass Surgery on Fasting and Postprandial Concentrations of Plasma Ghrelin, Peptide YY, and Insulin
J. Clin. Endocrinol. Metab., January 1, 2005; 90(1): 359 - 365.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
K. Rahmouni, M. L.G. Correia, W. G. Haynes, and A. L. Mark
Obesity-Associated Hypertension: New Insights Into Mechanisms
Hypertension, January 1, 2005; 45(1): 9 - 14.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
K. Dezaki, H. Hosoda, M. Kakei, S. Hashiguchi, M. Watanabe, K. Kangawa, and T. Yada
Endogenous Ghrelin in Pancreatic Islets Restricts Insulin Release by Attenuating Ca2+ Signaling in {beta}-Cells: Implication in the Glycemic Control in Rodents
Diabetes, December 1, 2004; 53(12): 3142 - 3151.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. Y. Jeon, S. Lee, H. H. Kim, Y. J. Kim, H. C. Son, D. H. Kim, and M. S. Sim
Changes in Plasma Ghrelin Concentration Immediately after Gastrectomy in Patients with Early Gastric Cancer
J. Clin. Endocrinol. Metab., November 1, 2004; 89(11): 5392 - 5396.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. Conus, D. B. Allison, R. Rabasa-Lhoret, M. St-Onge, D. H. St-Pierre, A. Tremblay-Lebeau, and E. T. Poehlman
Metabolic and Behavioral Characteristics of Metabolically Obese but Normal-Weight Women
J. Clin. Endocrinol. Metab., October 1, 2004; 89(10): 5013 - 5020.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. Maier, G. Schaller, B. Buranyi, P. Nowotny, G. Geyer, M. Wolzt, and A. Luger
The Cholinergic System Controls Ghrelin Release and Ghrelin-Induced Growth Hormone Release in Humans
J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4729 - 4733.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. O. Yildiz, M. A. Suchard, M.-L. Wong, S. M. McCann, and J. Licinio
Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity
PNAS, July 13, 2004; 101(28): 10434 - 10439.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Bellone, N. Castellino, F. Broglio, A. Rapa, D. Vivenza, G. Radetti, J. Bellone, C. Gottero, E. Ghigo, and G. Bona
Ghrelin Secretion in Childhood Is Refractory to the Inhibitory Effect of Feeding
J. Clin. Endocrinol. Metab., April 1, 2004; 89(4): 1662 - 1665.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2003 by the American Diabetes Association.