Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Okada, S.
Right arrow Articles by Makino, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Okada, S.
Right arrow Articles by Makino, H.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes 52:2586-2593, 2003
© 2003 by the American Diabetes Association, Inc.

Intercellular Adhesion Molecule-1–Deficient Mice Are Resistant Against Renal Injury After Induction of Diabetes

Shinichi Okada, Kenichi Shikata, Mitsuhiro Matsuda, Daisuke Ogawa, Hitomi Usui, Yuichi Kido, Ryo Nagase, Jun Wada, Yasushi Shikata, and Hirofumi Makino

From the Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan

Diabetic nephropathy is a leading cause of end-stage renal failure. Several mechanisms, including activation of protein kinase C, advanced glycation end products, and overexpression of transforming growth factor (TGF)-ß, are believed to be involved in the pathogenesis of diabetic nephropathy. However, the significance of inflammatory processes in the pathogenesis of diabetic microvascular complications is poorly understood. Accumulation of macrophages and overexpression of leukocyte adhesion molecules and chemokines are prominent in diabetic human kidney tissues. We previously demonstrated that intercellular adhesion molecule (ICAM)-1 mediates macrophage infiltration into the diabetic kidney. In the present study, to investigate the role of ICAM-1 in diabetic nephropathy, we induced diabetes in ICAM-1–deficient (ICAM-1-/-) mice and ICAM-1+/+ mice with streptozotocin and examined the renal pathology over a period of 6 months. The infiltration of macrophages was markedly suppressed in diabetic ICAM-1-/- mice compared with that of ICAM-1+/+ mice. Urinary albumin excretion, glomerular hypertrophy, and mesangial matrix expansion were significantly lower in diabetic ICAM-1-/- mice than in diabetic ICAM-1+/+ mice. Moreover, expressions of TGF-ß and type IV collagen in glomeruli were also suppressed in diabetic ICAM-1-/- mice. These results suggest that ICAM-1 is critically involved in the pathogenesis of diabetic nephropathy.

Address correspondence and reprint requests to Kenichi Shikata, MD, Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. E-mail: shikata{at}md.okayama-u.ac.jp


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 DiabetesHome page
Y. Qian, E. Feldman, S. Pennathur, M. Kretzler, and F. C. Brosius III
From Fibrosis to Sclerosis: Mechanisms of Glomerulosclerosis in Diabetic Nephropathy
Diabetes, June 1, 2008; 57(6): 1439 - 1445.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. Liu, L. Shi, and S. Wang
Overexpression of upstream stimulatory factor 2 accelerates diabetic kidney injury
Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1727 - F1735.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. J. Williams, G. Qiu, H. K. Usui, S. R. Dunn, P. McCue, E. Bottinger, R. V. Iozzo, and K. Sharma
Decorin Deficiency Enhances Progressive Nephropathy in Diabetic Mice
Am. J. Pathol., November 1, 2007; 171(5): 1441 - 1450.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
Y. Hamada, S. Miyata, T. Nii-Kono, R. Kitazawa, S. Kitazawa, S. Higo, M. Fukunaga, S. Ueyama, H. Nakamura, J. Yodoi, et al.
Overexpression of thioredoxin1 in transgenic mice suppresses development of diabetic nephropathy
Nephrol. Dial. Transplant., June 1, 2007; 22(6): 1547 - 1557.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
Y. Kanetsuna, K. Takahashi, M. Nagata, M. A. Gannon, M. D. Breyer, R. C. Harris, and T. Takahashi
Deficiency of Endothelial Nitric-Oxide Synthase Confers Susceptibility to Diabetic Nephropathy in Nephropathy-Resistant Inbred Mice
Am. J. Pathol., May 1, 2007; 170(5): 1473 - 1484.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. Ohga, K. Shikata, K. Yozai, S. Okada, D. Ogawa, H. Usui, J. Wada, Y. Shikata, and H. Makino
Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-{kappa}B activation
Am J Physiol Renal Physiol, April 1, 2007; 292(4): F1141 - F1150.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
S. Lee, W. Kim, S.-O. Moon, M. J. Sung, D. H. Kim, K. P. Kang, K. Y. Jang, S. Y. Lee, B. H. Park, G. Y. Koh, et al.
Renoprotective effect of COMP-angiopoietin-1 in db/db mice with type 2 diabetes
Nephrol. Dial. Transplant., February 1, 2007; 22(2): 396 - 408.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
H. K. Usui, K. Shikata, M. Sasaki, S. Okada, M. Matsuda, Y. Shikata, D. Ogawa, Y. Kido, R. Nagase, K. Yozai, et al.
Macrophage Scavenger Receptor-A-Deficient Mice Are Resistant Against Diabetic Nephropathy Through Amelioration of Microinflammation
Diabetes, February 1, 2007; 56(2): 363 - 372.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
X. Zhang, X. Chen, Q. Hong, H. Lin, H. Zhu, Q. Liu, J. Wang, Y. Xie, X. Shang, S. Shi, et al.
TIMP-1 Promotes Age-Related Renal Fibrosis Through Upregulating ICAM-1 in Human TIMP-1 Transgenic Mice
J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2006; 61(11): 1130 - 1143.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
S. Giunti, D. Barit, and M. E. Cooper
Mechanisms of Diabetic Nephropathy: Role of Hypertension
Hypertension, October 1, 2006; 48(4): 519 - 526.
[Full Text] [PDF]

Home page
 DiabetesHome page
T. Okada, J. Wada, K. Hida, J. Eguchi, I. Hashimoto, M. Baba, A. Yasuhara, K. Shikata, and H. Makino
Thiazolidinediones Ameliorate Diabetic Nephropathy via Cell Cycle-Dependent Mechanisms
Diabetes, June 1, 2006; 55(6): 1666 - 1677.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
S. C.W. Tang, J. C.K. Leung, L. Y.Y. Chan, A. W.L. Tsang, and K. N. Lai
Activation of Tubular Epithelial Cells in Diabetic Nephropathy and the Role of the Peroxisome Proliferator-Activated Receptor-{gamma} Agonist
J. Am. Soc. Nephrol., June 1, 2006; 17(6): 1633 - 1643.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
S. X. Zhang, J. J. Wang, K. Lu, R. Mott, R. Longeras, and J.-x. Ma
Therapeutic Potential of Angiostatin in Diabetic Nephropathy
J. Am. Soc. Nephrol., February 1, 2006; 17(2): 475 - 486.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
E. Galkina and K. Ley
Leukocyte Recruitment and Vascular Injury in Diabetic Nephropathy
J. Am. Soc. Nephrol., February 1, 2006; 17(2): 368 - 377.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
T. Kosugi, Y. Yuzawa, W. Sato, H. Kawai, S. Matsuo, Y. Takei, T. Muramatsu, and K. Kadomatsu
Growth Factor Midkine Is Involved in the Pathogenesis of Diabetic Nephropathy
Am. J. Pathol., January 1, 2006; 168(1): 9 - 19.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
A. Nakamura, K. Shikata, M. Hiramatsu, T. Nakatou, T. Kitamura, J. Wada, T. Itoshima, and H. Makino
Serum Interleukin-18 Levels Are Associated With Nephropathy and Atherosclerosis in Japanese Patients With Type 2 Diabetes
Diabetes Care, December 1, 2005; 28(12): 2890 - 2895.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
K. G. Ewens, R. A. George, K. Sharma, F. N. Ziyadeh, and R. S. Spielman
Assessment of 115 Candidate Genes for Diabetic Nephropathy by Transmission/Disequilibrium Test
Diabetes, November 1, 2005; 54(11): 3305 - 3318.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
K. Yozai, K. Shikata, M. Sasaki, A. Tone, S. Ohga, H. Usui, S. Okada, J. Wada, R. Nagase, D. Ogawa, et al.
Methotrexate Prevents Renal Injury in Experimental Diabetic Rats via Anti-Inflammatory Actions
J. Am. Soc. Nephrol., November 1, 2005; 16(11): 3326 - 3338.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M. Baba, J. Wada, J. Eguchi, I. Hashimoto, T. Okada, A. Yasuhara, K. Shikata, Y. S. Kanwar, and H. Makino
Galectin-9 Inhibits Glomerular Hypertrophy in db/db Diabetic Mice via Cell-Cycle-Dependent Mechanisms
J. Am. Soc. Nephrol., November 1, 2005; 16(11): 3222 - 3234.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
F. Y. Chow, D. J. Nikolic-Paterson, E. Ozols, R. C. Atkins, and G. H. Tesch
Intercellular Adhesion Molecule-1 Deficiency Is Protective against Nephropathy in Type 2 Diabetic db/db Mice
J. Am. Soc. Nephrol., June 1, 2005; 16(6): 1711 - 1722.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
W. Wang, X. R. Huang, A. G. Li, F. Liu, J.-H. Li, L. D. Truong, X. J. Wang, and H. Y. Lan
Signaling Mechanism of TGF-{beta}1 in Prevention of Renal Inflammation: Role of Smad7
J. Am. Soc. Nephrol., May 1, 2005; 16(5): 1371 - 1383.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
E. M. Stuveling, S. J. L. Bakker, H. L. Hillege, P. E. de Jong, R. O. B. Gans, and D. de Zeeuw
Biochemical risk markers: a novel area for better prediction of renal risk?
Nephrol. Dial. Transplant., March 1, 2005; 20(3): 497 - 508.
[Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
G. Gruden, G. Setti, A. Hayward, D. Sugden, S. Duggan, D. Burt, R. E. Buckingham, L. Gnudi, and G. Viberti
Mechanical Stretch Induces Monocyte Chemoattractant Activity via an NF-{kappa}B-Dependent Monocyte Chemoattractant Protein-1-Mediated Pathway in Human Mesangial Cells: Inhibition by Rosiglitazone
J. Am. Soc. Nephrol., March 1, 2005; 16(3): 688 - 696.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
Y. Yamamoto, Y. Maeshima, H. Kitayama, S. Kitamura, Y. Takazawa, H. Sugiyama, Y. Yamasaki, and H. Makino
Tumstatin Peptide, an Inhibitor of Angiogenesis, Prevents Glomerular Hypertrophy in the Early Stage of Diabetic Nephropathy
Diabetes, July 1, 2004; 53(7): 1831 - 1840.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2003 by the American Diabetes Association.