HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Purnell, J. Q. Articles by Brunzell, J. D. Search for Related Content PubMed PubMed Citation Articles by Purnell, J. Q. Articles by Brunzell, J. D. Social Bookmarking                What's this?

Relationship of Family History of Type 2 Diabetes, Hypoglycemia, and Autoantibodies to Weight Gain and Lipids With Intensive and Conventional Therapy in the Diabetes Control and Complications Trial

¹ Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health & Science University, Portland, Oregon
² Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, Washington
³ University of Minnesota, Minneapolis, Minnesota
⁴ George Washington University, Rockville, Maryland
⁵ University of Colorado, Denver, Colorado

Intensive therapy for type 1 diabetes results in greater weight gain than conventional therapy. Many factors may predispose to this greater weight gain, including improved glycemic control, genetic susceptibility to obesity, and hypoglycemia. To study this, relationships among family history of type 2 diabetes, frequency of severe hypoglycemia, ß-cell autoantibodies, and weight gain were examined in 1,168 subjects aged 18 years at baseline randomized to intensive and conventional therapy groups in the Diabetes Control and Complications Trial. With intensive therapy, subjects with a family history of type 2 diabetes had greater central weight gain and dyslipidemia characterized by higher triglyceride levels and greater cholesterol in VLDLs and intermediate-density lipoproteins compared with subjects with no family history. Neither the frequency of severe hypoglycemia nor positivity to GAD65 and insulinoma-associated protein 2 antibodies was associated with increased weight gain with either intensive or conventional therapy. These data support the hypothesis that increased weight gain with intensive therapy might be explained, in part, by genetic traits.

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				I. H. de Boer, S. D. Sibley, B. Kestenbaum, J. N. Sampson, B. Young, P. A. Cleary, M. W. Steffes, N. S. Weiss, J. D. Brunzell, and for the Diabetes Control and Complications Trial/E Central Obesity, Incident Microalbuminuria, and Change in Creatinine Clearance in the Epidemiology of Diabetes Interventions and Complications Study J. Am. Soc. Nephrol., January 1, 2007; 18(1): 235 - 243. [Abstract] [Full Text] [PDF]

				T. J. Orchard, T. Costacou, A. Kretowski, and R. W. Nesto Type 1 diabetes and coronary artery disease. Diabetes Care, November 1, 2006; 29(11): 2528 - 2538. [Full Text] [PDF]

				S. M. Strowig and P. Raskin The Effect of Rosiglitazone on Overweight Subjects With Type 1 Diabetes Diabetes Care, July 1, 2005; 28(7): 1562 - 1567. [Abstract] [Full Text] [PDF]