Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kubaszek, A.
Right arrow Articles by Laakso, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kubaszek, A.
Right arrow Articles by Laakso, M.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes 52:558-561, 2003
© 2003 by the American Diabetes Association, Inc.

Brief Genetics Reports

The C-174G Promoter Polymorphism of the IL-6 Gene Affects Energy Expenditure and Insulin Sensitivity

Agata Kubaszek1, Jussi Pihlajamäki1, Kari Punnonen2, Pauli Karhapää1, Ilkka Vauhkonen1, and Markku Laakso1

1 Department of Medicine, University of Kuopio, Kuopio, Finland
2 Department of Clinical Chemistry, University of Kuopio, Kuopio, Finland

Interleukin-6 (IL-6) is a pleiotropic cytokine expressed in many tissues. IL-6 null mice show low energy expenditure, but the effect of the variants of the IL-6 gene on energy expenditure has not been previously studied in humans. Therefore, we investigated the effect of the C-174G promoter polymorphism of the IL-6 gene on energy expenditure, measured by indirect calorimetry in healthy Finnish subjects (n = 124). We also measured insulin sensitivity by the hyperinsulinemic-euglycemic clamp. Subjects with the C-174C genotype of the IL-6 gene had significantly lower energy expenditure than subjects with the G-174C or G-174G genotypes both in fasting (CC 13.68 ± 1.98, CG 14.73 ± 1.57, GG 14.81 ± 2.01 kcal · kg-1 · min-1; P = 0.012) and during the euglycemic-hyperinsulinemic clamp (CC 15.24 ± 2.05, CG 16.62 ± 2.06, GG 16.66 ± 2.50 kcal · kg-1 · min-1; P = 0.007). Moreover, subjects homozygous for the C allele had lower rates of whole-body glucose uptake than carriers of the G allele (CC 50.95 ± 13.91, CG 59.40 ± 14.17, GG 59.21 ± 15.93 µmol · kg-1 · min-1; P = 0.016). The rates of both oxidative (P = 0.013) and nonoxidative (P = 0.016) glucose disposal were significantly affected by the IL-6 promoter polymorphism. In conclusion, the C-174C promoter polymorphism of the IL-6 gene influences energy expenditure and insulin sensitivity in healthy normoglycemic subjects. Whether this polymorphism is a risk factor for obesity or type 2 diabetes can be estimated only in prospective population-based studies.


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
L. Qi, C. Zhang, R. M. van Dam, and F. B. Hu
Interleukin-6 Genetic Variability and Adiposity: Associations in Two Prospective Cohorts and Systematic Review in 26,944 Individuals
J. Clin. Endocrinol. Metab., September 1, 2007; 92(9): 3618 - 3625.
[Abstract] [Full Text] [PDF]

Home page
 AMERICAN JOURNAL OF LIFESTYLE MEDICINEHome page
B. K. Pedersen
State of the Art Reviews: Health Benefits Related to Exercise in Patients With Chronic Low-Grade Systemic Inflammation
American Journal of Lifestyle Medicine, August 1, 2007; 1(4): 289 - 298.
[Abstract] [PDF]

Home page
 J. Appl. Physiol.Home page
E. E. Spangenburg, S. E. Shoelson, C. Weigert, R. Lehmann, E. D. Schleicher, J.-O. Jansson, V. Wallenius, J.-P. Bastard, C. Lagathu, M. Caron, et al.
Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis
J Appl Physiol, February 1, 2007; 102(2): 820 - 823.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. R. Steinberg, A. J. McAinch, M. B. Chen, P. E. O'Brien, J. B. Dixon, D. Cameron-Smith, and B. E. Kemp
The Suppressor of Cytokine Signaling 3 Inhibits Leptin Activation of AMP-Kinase in Cultured Skeletal Muscle of Obese Humans
J. Clin. Endocrinol. Metab., September 1, 2006; 91(9): 3592 - 3597.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
I. Wernstedt, A. Edgley, A. Berndtsson, J. Faldt, G. Bergstrom, V. Wallenius, and J.-O. Jansson
Reduced stress- and cold-induced increase in energy expenditure in interleukin-6-deficient mice
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R551 - R557.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L. Strandberg, M. Lorentzon, A. Hellqvist, S. Nilsson, V. Wallenius, C. Ohlsson, and J.-O. Jansson
Interleukin-1 System Gene Polymorphisms Are Associated with Fat Mass in Young Men
J. Clin. Endocrinol. Metab., July 1, 2006; 91(7): 2749 - 2754.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
L. Qi, R. M. van Dam, J. B. Meigs, J. E. Manson, D. Hunter, and F. B. Hu
Genetic variation in IL6 gene and type 2 diabetes: tagging-SNP haplotype analysis in large-scale case-control study and meta-analysis
Hum. Mol. Genet., June 1, 2006; 15(11): 1914 - 1920.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. C. Garcia, I. Wernstedt, A. Berndtsson, M. Enge, M. Bell, O. Hultgren, M. Horn, B. Ahren, S. Enerback, C. Ohlsson, et al.
Mature-onset obesity in interleukin-1 receptor I knockout mice.
Diabetes, May 1, 2006; 55(5): 1205 - 1213.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
O. P. Kristiansen and T. Mandrup-Poulsen
Interleukin-6 and Diabetes: The Good, the Bad, or the Indifferent?
Diabetes, December 1, 2005; 54(suppl_2): S114 - S124.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. Sesti, L. Perego, M. Cardellini, F. Andreozzi, C. Ricasoli, P. Vedani, V. Guzzi, M. Marchi, M. Paganelli, G. Ferla, et al.
Impact of Common Polymorphisms in Candidate Genes for Insulin Resistance and Obesity on Weight Loss of Morbidly Obese Subjects after Laparoscopic Adjustable Gastric Banding and Hypocaloric Diet
J. Clin. Endocrinol. Metab., September 1, 2005; 90(9): 5064 - 5069.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
M. Cardellini, L. Perego, M. D'Adamo, M. A. Marini, C. Procopio, M. L. Hribal, F. Andreozzi, S. Frontoni, M. Giacomelli, M. Paganelli, et al.
C-174G Polymorphism in the Promoter of the Interleukin-6 Gene Is Associated With Insulin Resistance
Diabetes Care, August 1, 2005; 28(8): 2007 - 2012.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. M. W. Petersen and B. K. Pedersen
The anti-inflammatory effect of exercise
J Appl Physiol, April 1, 2005; 98(4): 1154 - 1162.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
H. Wang, Z. Zhang, W. Chu, T. Hale, J. J. Cooper, and S. C. Elbein
Molecular Screening and Association Analyses of the Interleukin 6 Receptor Gene Variants with Type 2 Diabetes, Diabetic Nephropathy, and Insulin Sensitivity
J. Clin. Endocrinol. Metab., February 1, 2005; 90(2): 1123 - 1129.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
H. Staiger, K. Staiger, N. Stefan, H. G. Wahl, F. Machicao, M. Kellerer, and H.-U. Haring
Palmitate-Induced Interleukin-6 Expression in Human Coronary Artery Endothelial Cells
Diabetes, December 1, 2004; 53(12): 3209 - 3216.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. Bennermo, C. Held, S. Stemme, C.-G. Ericsson, A. Silveira, F. Green, and P. Tornvall
Genetic Predisposition of the Interleukin-6 Response to Inflammation: Implications for a Variety of Major Diseases?
Clin. Chem., November 1, 2004; 50(11): 2136 - 2140.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. Illig, F. Bongardt, A. Schopfer, S. Muller-Scholze, W. Rathmann, W. Koenig, B. Thorand, C. Vollmert, R. Holle, H. Kolb, et al.
Significant Association of the Interleukin-6 Gene Polymorphisms C-174G and A-598G with Type 2 Diabetes
J. Clin. Endocrinol. Metab., October 1, 2004; 89(10): 5053 - 5058.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. A. McKenzie, E. P. Weiss, I. A. Ghiu, O. Kulaputana, D. A. Phares, R. E. Ferrell, and J. M. Hagberg
Influence of the interleukin-6 -174 G/C gene polymorphism on exercise training-induced changes in glucose tolerance indexes
J Appl Physiol, October 1, 2004; 97(4): 1338 - 1342.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Mohlig, H. Boeing, J. Spranger, M. Osterhoff, A. Kroke, E. Fisher, M. M. Bergmann, M. Ristow, K. Hoffmann, and A. F. H. Pfeiffer
Body Mass Index and C-174G Interleukin-6 Promoter Polymorphism Interact in Predicting Type 2 Diabetes
J. Clin. Endocrinol. Metab., April 1, 2004; 89(4): 1885 - 1890.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. Rotter, I. Nagaev, and U. Smith
Interleukin-6 (IL-6) Induces Insulin Resistance in 3T3-L1 Adipocytes and Is, Like IL-8 and Tumor Necrosis Factor-{alpha}, Overexpressed in Human Fat Cells from Insulin-resistant Subjects
J. Biol. Chem., November 14, 2003; 278(46): 45777 - 45784.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
A. Kubaszek, J. Pihlajamaki, V. Komarovski, V. Lindi, J. Lindstrom, J. Eriksson, T. T. Valle, H. Hamalainen, P. Ilanne-Parikka, S. Keinanen-Kiukaanniemi, et al.
Promoter Polymorphisms of the TNF-{alpha} (G-308A) and IL-6 (C-174G) Genes Predict the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes: The Finnish Diabetes Prevention Study
Diabetes, July 1, 2003; 52(7): 1872 - 1876.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. M. Fernandez-Real and W. Ricart
Insulin Resistance and Chronic Cardiovascular Inflammatory Syndrome
Endocr. Rev., June 1, 2003; 24(3): 278 - 301.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2003 by the American Diabetes Association.