|
 |
|
|||||||
|
|||||||||
Diabetes 52:1182-1186, 2003
© 2003 by the American Diabetes Association, Inc.
Circulating Adiponectin Levels Are Reduced in Nonobese but Insulin-Resistant First-Degree Relatives of Type 2 Diabetic Patients
1 The Lundberg Laboratory for Diabetes Research, the Sahlgrenska Academy at Göteborg University, Göteborg, Sweden
2 Department of Internal Medicine and Molecular Science, Osaka University, Osaka, Japan
3 Department of Clinical Nutrition, the Sahlgrenska Academy at Göteborg University, Göteborg, Sweden
4 Wallenberg Laboratory for Cardiovascular Research, the Sahlgrenska Academy at Göteborg University, Göteborg, Sweden
5 Department of Medicine, University of Helsinki, Helsinki, Finland
Adiponectin, one of the most abundant gene transcript proteins in human fat cells, has been shown to improve insulin action and is also suggested to exert antiatherogenic effects. We measured circulating adiponectin levels and risk factors for atherosclerosis in 45 healthy first-degree relatives of type 2 diabetic subjects (FDR) as well as 40 healthy control subjects (CON) without a known family history of diabetes. Insulin sensitivity (Si) was studied with the minimal model, and measurements of adiponectin, metabolic variables, inflammatory markers, and endothelial injury markers, as well as lipoprotein concentrations, were performed. FDR were insulin resistant (3.3 ± 2.4 vs. 4.5 ± 2.6 x 10-4 x min-1 per µU/ml [mean ± SD], P < 0.01), and their circulating plasma adiponectin levels (6.6 ± 1.8 vs. 8.1 ± 3.0 µg/ml, P < 0.03) were decreased. After adjustments for age in FDR, adiponectin levels were negatively correlated with fasting proinsulin (r -0.64, P < 0.001), plasminogen activator inhibitor (PAI)-1 activity (r -0.56, P < 0.001), fasting insulin (r -0.55, P < 0.001), and acute insulin response (r -0.40, P < 0.05); they were positively related to HDL cholesterol (r 0.48, P < 0.01) and Si (r 0.41, P < 0.01). Furthermore, when adjusted for age, waist, and Si, adiponectin was associated with HDL cholesterol and proinsulin, which explained 51% of the variation in adiponectin in multiple regression analyses in that group. In conclusion, circulating plasma adiponectin levels were decreased in nonobese but insulin-resistant FDR and, in addition, related to several facets of the insulin resistance syndrome (IRS). Thus, hypoadiponectinemia may be an important component of the association between cardiovascular disease and IRS.
CiteULike 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  Z. Punthakee, E. E. Delvin, J. O'Loughlin, G. Paradis, E. Levy, R. W. Platt, and M. Lambert Adiponectin, Adiposity, and Insulin Resistance in Children and Adolescents J. Clin. Endocrinol. Metab., June 1, 2006; 91(6): 2119 - 2125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lopez-Soriano, C. Chiellini, M. Maffei, P. A. Grimaldi, and J. M. Argiles Roles of Skeletal Muscle and Peroxisome Proliferator-Activated Receptors in the Development and Treatment of Obesity Endocr. Rev., May 1, 2006; 27(3): 318 - 329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Kowalska, M. Straczkowski, A. Nikolajuk, A. Krukowska, I. Kinalska, and M. Gorska Plasma adiponectin concentration and tumor necrosis factor-{alpha} system activity in lean non-diabetic offspring of type 2 diabetic subjects Eur. J. Endocrinol., February 1, 2006; 154(2): 319 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Salmenniemi, J. Zacharova, E. Ruotsalainen, I. Vauhkonen, J. Pihlajamaki, S. Kainulainen, K. Punnonen, and M. Laakso Association of Adiponectin Level and Variants in the Adiponectin Gene with Glucose Metabolism, Energy Expenditure, and Cytokines in Offspring of Type 2 Diabetic Patients J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 4216 - 4223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Sepilian and M. Nagamani Adiponectin Levels in Women With Polycystic Ovary Syndrome and Severe Insulin Resistance Reproductive Sciences, February 1, 2005; 12(2): 129 - 134. [Abstract] [PDF]
|
|
|
|
 |
|
 S Kaser, A Moschen, A Cayon, A Kaser, J Crespo, F Pons-Romero, C F Ebenbichler, J R Patsch, and H Tilg Adiponectin and its receptors in non-alcoholic steatohepatitis Gut, January 1, 2005; 54(1): 117 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-k. Park, S.-Y. Oh, M.-Y. Lee, S. Yoon, K.-S. Kim, and J.-w. Kim CCAAT/Enhancer Binding Protein and Nuclear Factor-Y Regulate Adiponectin Gene Expression in Adipose Tissue Diabetes, November 1, 2004; 53(11): 2757 - 2766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Winzer, O. Wagner, A. Festa, B. Schneider, M. Roden, D. Bancher-Todesca, G. Pacini, T. Funahashi, and A. Kautzky-Willer Plasma Adiponectin, Insulin Sensitivity, and Subclinical Inflammation in Women With Prior Gestational Diabetes Mellitus Diabetes Care, July 1, 2004; 27(7): 1721 - 1727. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Short, K. S. Nair, C. S. Stump, M. Bajaj, L. J. Mandarino, P. J. Raubenheimer, M. Mohlig, F. Isken, M. Ristow, K. F. Petersen, et al. Impaired Mitochondrial Activity and Insulin-Resistant Offspring of Patients with Type 2 Diabetes N. Engl. J. Med., June 3, 2004; 350(23): 2419 - 2421. [Full Text] [PDF]
|
|
|
|
|
|
J. Hoffstedt, E. Arvidsson, E. Sjolin, K. Wahlen, and P. Arner Adipose Tissue Adiponectin Production and Adiponectin Serum Concentration in Human Obesity and Insulin Resistance J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1391 - 1396. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Suominen Evaluation of an Enzyme Immunometric Assay to Measure Serum Adiponectin Concentrations Clin. Chem., January 1, 2004; 50(1): 219 - 221. [Full Text] [PDF]
|
|
|
|
 |
|
 H. Chen, M. Montagnani, T. Funahashi, I. Shimomura, and M. J. Quon Adiponectin Stimulates Production of Nitric Oxide in Vascular Endothelial Cells J. Biol. Chem., November 7, 2003; 278(45): 45021 - 45026. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Diabetes | Diabetes Care | Clinical Diabetes | Diabetes Spectrum |