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Diabetes 52:1591-1594, 2003
© 2003 by the American Diabetes Association, Inc.

Rapid Publication

Magnetic Resonance-Defined Periportal Steatosis Following Intraportal Islet Transplantation

A Functional Footprint of Islet Graft Survival?

James F. Markmann1, Mark Rosen2, Evan S. Siegelman2, Michael C. Soulen2, Shaoping Deng1, Clyde F. Barker1, and Ali Naji1

1 Department of Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania
2 Department of Radiology, University of Pennsylvania Health System, Philadelphia, Pennsylvania

There is growing interest in more widespread application of isolated islet transplantation for the treatment of type 1 diabetes; however, the sequelae of long-term islet residence within the liver are unknown. We report herein a consequence of intraportal islet transplantation, specifically the development of periportal hepatic steatosis apparently induced by the local secretion of insulin within the liver.

Address correspondence and reprint requests to James F. Markmann, MD, Department of Surgery, Hospital of the University of Pennsylvania, 4th Floor Silverstein, 3400 Spruce St., Philadelphia, PA 19104. E-mail: james.markmann{at}uphs.upenn.edu


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