Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Giusti, V.
Right arrow Articles by Pralong, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Giusti, V.
Right arrow Articles by Pralong, F.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes 52:1673-1676, 2003
© 2003 by the American Diabetes Association, Inc.

Expression of Peroxisome Proliferator-Activated Receptor-{gamma}1 and Peroxisome Proliferator-Activated Receptor-{gamma}2 in Visceral and Subcutaneous Adipose Tissue of Obese Women

Vittorio Giusti1, Chantal Verdumo1, Michel Suter2, Rolf Christian Gaillard3, Peter Burckhardt1, and Francois Pralong3

1 Department of Internal Medicine, Diabetology and Metabolism Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
2 Department of Surgery, Diabetology and Metabolism Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
3 Division of Endocrinology, Diabetology and Metabolism Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

Data regarding the expression of peroxisome proliferator-activated receptor (PPAR)-{gamma}1 and PPAR-{gamma}2 in human visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) are conflicting. To clarify this issue, we studied 50 women who had a BMI >35 kg/m2 were undergoing gastric reduction surgery. Phenotyping included recording of anthropometric parameters and of a biological profile. Quantification of the expression of PPAR-{gamma}1 and PPAR-{gamma}2 in samples of VAT and SAT was performed by real-time RT-PCR. In both SAT and VAT, the level of expression of PPAR-{gamma}2 were >20-fold that of PPAR-{gamma}1 (P < 0.001 for both). However, only PPAR-{gamma}1 was differentially expressed, its levels in SAT being 216 ± 34% those in VAT (P < 0.001). In a stepwise, multivariate regression analysis, the levels of PPAR-{gamma}1 in both SAT and VAT were the major determinants of waist circumference (R2 = 21% for both; P < 0.01). Finally, leptin but not PPARs appeared as the single parameter explaining the largest part of the variability of BMI in our cohort of patients (R2 = 22%, P < 0.001). These results are consistent with the putative roles of PPAR-{gamma}1 and PPAR-{gamma}2 in carbohydrate metabolism and energy homeostasis, respectively. As such, they constitute an important step toward the identification of potential targets for novel therapeutic strategies in the fields of obesity.

Address correspondence and reprint requests to Vittorio Giusti, MD, Department of Internal Medicine, Centre Hospitalier Universitaire, Vaudois, 1011 Lausanne, Switzerland. E-mail: vittorio.giusti{at}chuv.hospvd.ch


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
S. E. Feldon, C. W. O'Loughlin, D. M. Ray, S. Landskroner-Eiger, K. E. Seweryniak, and R. P. Phipps
Activated Human T Lymphocytes Express Cyclooxygenase-2 and Produce Proadipogenic Prostaglandins that Drive Human Orbital Fibroblast Differentiation to Adipocytes
Am. J. Pathol., October 1, 2006; 169(4): 1183 - 1193.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. H. Pietilainen, K. Kannisto, E. Korsheninnikova, A. Rissanen, J. Kaprio, E. Ehrenborg, A. Hamsten, and H. Yki-Jarvinen
Acquired Obesity Increases CD68 and Tumor Necrosis Factor-{alpha} and Decreases Adiponectin Gene Expression in Adipose Tissue: A Study in Monozygotic Twins
J. Clin. Endocrinol. Metab., July 1, 2006; 91(7): 2776 - 2781.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. Salvi, E. Castillo, M.-J. Voirol, M. Glauser, J.-P. Rey, R. C. Gaillard, P. Vollenweider, and F. P. Pralong
Gonadotropin-Releasing Hormone-Expressing Neurons Immortalized Conditionally Are Activated by Insulin: Implication of the Mitogen-Activated Protein Kinase Pathway
Endocrinology, February 1, 2006; 147(2): 816 - 826.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
V. Giusti, M. Suter, C. Verdumo, R. C. Gaillard, P. Burckhardt, and F. P. Pralong
Molecular Determinants of Human Adipose Tissue: Differences between Visceral and Subcutaneous Compartments in Obese Women
J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1379 - 1384.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. Burcelin, B. Thorens, M. Glauser, R. C. Gaillard, and F. P. Pralong
Gonadotropin-Releasing Hormone Secretion from Hypothalamic Neurons: Stimulation by Insulin and Potentiation by Leptin
Endocrinology, October 1, 2003; 144(10): 4484 - 4491.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2003 by the American Diabetes Association.