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Diabetes 52:2097-2101, 2003
© 2003 by the American Diabetes Association, Inc.

Inflammation-Sensitive Plasma Proteins Are Associated With Future Weight Gain

Gunnar Engström1, Bo Hedblad1, Lars Stavenow2, Peter Lind2, Lars Janzon1, and Folke Lindgärde3

1 Department of Community Medicine, Lund University, Malmö, Sweden
2 Department of Medicine, Lund University, Malmö, Sweden
3 Department of Vascular Diseases, Lund University, Malmö, Sweden

Cross-sectional studies have associated obesity and other components of the so-called metabolic syndrome with low-grade inflammation. The temporal and causal relations of this association have not been fully explored. This study explored whether elevated levels of inflammation-sensitive plasma proteins (ISPs) (fibrinogen, orosomucoid, {alpha}1-antitrypsin, haptoglobin, and ceruloplasmin) are associated with future weight gain. Five ISPs were measured in 2,821 nondiabetic healthy men (38–50 years of age) who were reexamined after a mean follow-up of 6.1 years. Future weight gain was studied in relation to the number of elevated ISPs (i.e., in the top quartile). The proportion with a large weight gain (75th percentile >=3.8 kg) was 21.0, 25.9, 26.8, and 28.3%, respectively, among men with none, one, two, and three or more ISPs in the top quartile (P for trend 0.0005). This relation remained significant after adjustments for weight at baseline, follow-up time, height (at baseline and follow-up), physical inactivity (at baseline and follow-up), smoking (at baseline and follow-up), high alcohol consumption, and insulin resistance. The relations were largely similar for all individual ISPs. Elevated ISP levels predict a large weight gain in middle-aged men. This relation could contribute to the relation between inflammation, the metabolic syndrome, and cardiovascular disease.

Address correspondence and reprint requests to Gunnar Engström, MD, Department of Community Medicine, Malmö University Hospital, S-20502 Malmö, Sweden. E-mail: gunnar.engstrom{at}smi.mas.lu.se


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