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Diabetes 53:2735-2740, 2004
© 2004 by the American Diabetes Association, Inc.

Perspectives in Diabetes

Molecular Mechanisms of Insulin Resistance That Impact Cardiovascular Biology

Cecilia C. Low Wang, Marc L. Goalstone, and Boris Draznin

From the Research Service of the Denver Veterans Affairs Medical Center, and the Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado

Insulin resistance is concomitant with type 2 diabetes, obesity, hypertension, and other features of the metabolic syndrome. Because insulin resistance is associated with cardiovascular disease, both scientists and physicians have taken great interest in this disorder. Insulin resistance is associated with compensatory hyperinsulinemia, but individual contributions of either of these two conditions remain incompletely understood and a subject of intense investigation. One possibility is that in an attempt to overcome the inhibition within the metabolic insulin-signaling pathway, hyperinsulinemia may continue to stimulate the mitogenic insulin-signaling pathway, thus exerting its detrimental influence. Here we discuss some of the effects of insulin resistance and mechanisms of potentially detrimental influence of hyperinsulinemia in the presence of metabolic insulin resistance.

Address correspondence and reprint requests to Dr. Boris Draznin, ACOS for R&D (151), Denver VAMC, 1055 Clermont St, Denver, CO 80220. E-mail: boris.draznin{at}med.va.gov


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Copyright © 2004 by the American Diabetes Association.