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Diabetes 53:3323-3327, 2004
© 2004 by the American Diabetes Association, Inc.

Mapping Non–Class II H2-Linked Loci for Type 1 Diabetes in Nonobese Diabetic Mice

Nathalie Deruytter, Olivier Boulard, and Henri-Jean Garchon

INSERM U580 and Université Paris V-René Descartes, Paris, France

Major histocompatibility complex (MHC) plays a largely predominant role in the genetic predisposition to type 1 diabetes, in both humans and rodents. While class II loci have long been recognized as essential, they do not fully explain the MHC-linked genetic component of type 1 diabetes. In the present study, using new NOD congenic strains harboring defined chromosomal segments from C57BL/6 mice, we circumscribed three distinct loci influencing murine type 1 diabetes and tightly linked to but separated from the class II region. Our findings might guide the search for additional HLA-linked loci in human type 1 diabetes.

Address correspondence and reprint requests to Henri-Jean Garchon, INSERM U580, 161 rue de Sèvres, 75743 Paris cedex 15, France. E-mail: garchon{at}necker.fr


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Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2004 by the American Diabetes Association.