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Diabetes 53:838-841, 2004
© 2004 by the American Diabetes Association, Inc.

Brief Genetics Report

A Genome-Wide Search for Type 2 Diabetes Susceptibility Genes in West Africans

The Africa America Diabetes Mellitus (AADM) Study

Charles N. Rotimi1, Guanjie Chen1, Adebowale A. Adeyemo1,2, Paulette Furbert-Harris1, Debra Guass1, Jie Zhou1, Kate Berg3, Olufemi Adegoke1, Albert Amoah4, Samuel Owusu4, Joseph Acheampong5, Kofi Agyenim-Boateng5, Benjamin A. Eghan, Jr.5, Johnnie Oli6, Godfrey Okafor6, Ester Ofoegbu6, Babatunde Osotimehin2, Fayeofori Abbiyesuku2, Thomas Johnson7, Theresa Rufus7, Olufemi Fasanmade7, Rick Kittles1, Harold Daniel1, Yuanxiu Chen1, Georgia Dunston1, and Francis S. Collins3

1 Department of Microbiology, National Human Genome Center at Howard University, College of Medicine, Washington, DC
2 College of Medicine, University of Ibadan, Ibadan, Nigeria
3 National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland
4 Department of Medicine, University of Ghana Medical School, Accra, Ghana
5 Department of Medicine, University of Science and Technology, Kumasi, Ghana
6 Department of Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria
7 College of Medicine, Endocrine and Metabolic Unit, University of Lagos, Lagos, Nigeria

The incidence of type 2 diabetes is growing rapidly, not only in developed countries but also worldwide. We chose to study type 2 diabetes in West Africa, where diabetes is less common than in the U.S., reasoning that in an environment where calories are less abundant, incident cases of type 2 diabetes might carry a proportionately greater genetic component. Through the Africa America Diabetes Mellitus (AADM) study, we carried out a genome-wide linkage analysis of type 2 diabetes in a cohort of 343 affected sibling pairs (691 individuals) enrolled from five West African centers in two countries (Ghana: Accra and Kumasi; Nigeria: Enugu, Ibadan, and Lagos). A total of 390 polymorphic markers were genotyped, and multipoint linkage analysis was conducted using the GENEHUNTER-PLUS and ASM programs. Suggestive evidence of linkage was observed in four regions on three chromosomes (12, 19, and 20). The two largest logarithm of odds scores of 2.63 and 1.92 for chromosomes 20q13.3 and 12q24, respectively, are particularly interesting because these regions have been reported to harbor diabetes susceptibility genes in several other populations and ethnic groups. Given the history of forced migration of West African populations during the slave trade, these results should have considerable relevance to the study of type 2 diabetes in African Americans.

Address correspondence and reprint requests to Charles Rotimi, PhD, National Human Genome Center, Howard University, Genetic Epidemiology Unit, College of Medicine, 2216 6th St., NW, Washington, DC 20059. E-mail: crotimi{at}howard.edu


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Copyright © 2004 by the American Diabetes Association.