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Diabetes 53:1046-1051, 2004
© 2004 by the American Diabetes Association, Inc.

Diabetic Patients Without Vascular Complications Display Enhanced Basal Platelet Activation and Decreased Antioxidant Status

Evelyne Véricel1, Caroline Januel1, Martine Carreras1, Philippe Moulin1,2, and Michel Lagarde1

1 Unité mixte de Recherche 585 Institut National de la Santé et de la Recherche Médicale (INSERM)/Institut National des Sciences Appliquées de Lyon, Institute for Multidisciplinary Biochemistry of Lipids, Villeurbanne, France
2 Department of Endocrinology and Nutrition, Cardiovascular Hospital Louis Pradel, Bron, France

Vascular complications are the leading causes of morbidity and mortality in diabetic patients. The contribution of platelets to thromboembolic complications is well documented, but their involvement in the initiation of the atherosclerotic process is of rising interest. Thus, the aim of the present study was to evaluate basal arachidonic acid metabolism in relation to the redox status of platelets in both type 1 and type 2 diabetic patients, in the absence of vascular complications, as compared with respective control subjects. For the first time, we show that basal thromboxane B2, the stable catabolite of thromboxane A2, significantly increased in resting platelets from both type 1 and type 2 diabetic patients (58 and 88%, respectively), whereas platelet malondialdehyde level was only higher in platelets from type 2 diabetic subjects (67%). On the other hand, both vitamin E levels and cytosolic glutathione peroxidase activities were significantly lower in platelets from diabetic patients as compared with respective control subjects. We conclude that platelet hyperactivation was detectable in well-controlled diabetic patients without complications. This abnormality was associated with increased oxidative stress and impaired antioxidant defense in particular in type 2 diabetic patients. These alterations contribute to the increased risk for occurrence of vascular diseases in such patients.

Address correspondence and reprint requests to Dr. E. Véricel, UMR 585 INSERM/INSA-Lyon, Bâtiment Louis Pasteur, INSA-Lyon, 69621 Villeurbanne, France. E-mail: evelyne.vericel{at}insa-lyon.fr


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Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2004 by the American Diabetes Association.