HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kelly, J. F. Articles by Elmquist, J. K. Search for Related Content PubMed PubMed Citation Articles by Kelly, J. F. Articles by Elmquist, J. K. Social Bookmarking                What's this?

Ciliary Neurotrophic Factor and Leptin Induce Distinct Patterns of Immediate Early Gene Expression in the Brain

¹ Department of Medicine and Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts
² Department of Neurology and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts
³ Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
⁴ Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
⁵ Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio

Ciliary neurotrophic factor (CNTF) and leptin decrease food intake and body weight. Lipopolysaccharide (LPS) is a potent exogenous pyrogen and produces anorexia via cytokine production. CNTF-, leptin-, and LPS-induced cytokines all act on type I cytokine receptors. However, it is not known if these cytokines engage similar central nervous system (CNS) pathways to exert their effects. To assess mechanisms by which these cytokines act, we examined the patterns of immediate early gene expression (SOCS-3, c-fos, and tis-11) in the brain following intravenous administration. CNTF and LPS induced gene expression in circumventricular organs; ependymal cells of the ventricles, meninges, and choroid plexus; and the arcuate nucleus of the hypothalamus. CNTF administration also induced fever and cyclooxygenase-2 mRNA expression. In contrast, we found no evidence of leptin-induced inflammation. CNTF and leptin are being assessed as potential therapeutic antiobesity agents, and both potently reduce food intake. Our findings support the hypothesis that CNTF and leptin engage distinct CNS sites and CNTF possesses inflammatory properties distinct from leptin.

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				L. F Rezende, L. F Stoppiglia, K. L A Souza, A. Negro, F. Langone, and A. C Boschero Ciliary neurotrophic factor promotes survival of neonatal rat islets via the BCL-2 anti-apoptotic pathway J. Endocrinol., October 1, 2007; 195(1): 157 - 165. [Abstract] [Full Text] [PDF]

				R. Dutta, J. McDonough, A. Chang, L. Swamy, A. Siu, G. J. Kidd, R. Rudick, K. Mirnics, and B. D. Trapp Activation of the ciliary neurotrophic factor (CNTF) signalling pathway in cortical neurons of multiple sclerosis patients Brain, October 1, 2007; 130(10): 2566 - 2576. [Abstract] [Full Text] [PDF]

				L. Elander, L. Engstrom, M. Hallbeck, and A. Blomqvist IL-1beta and LPS induce anorexia by distinct mechanisms differentially dependent on microsomal prostaglandin E synthase-1 Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R258 - R267. [Abstract] [Full Text] [PDF]

				M. Fry, P. M. Smith, T. D. Hoyda, M. Duncan, R. S. Ahima, K. A. Sharkey, and A. V. Ferguson Area postrema neurons are modulated by the adipocyte hormone adiponectin. J. Neurosci., September 20, 2006; 26(38): 9695 - 9702. [Abstract] [Full Text] [PDF]

				G. R. Steinberg, M. J. Watt, B. C. Fam, J. Proietto, S. Andrikopoulos, A. M. Allen, M. A. Febbraio, and B. E. Kemp Ciliary Neurotrophic Factor Suppresses Hypothalamic AMP-Kinase Signaling in Leptin-Resistant Obese Mice Endocrinology, August 1, 2006; 147(8): 3906 - 3914. [Abstract] [Full Text] [PDF]

				R. Janoschek, L. Plum, L. Koch, H. Munzberg, S. Diano, M. Shanabrough, W. Muller, T. L. Horvath, and J. C. Bruning gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor PNAS, July 11, 2006; 103(28): 10707 - 10712. [Abstract] [Full Text] [PDF]

				M. Lopez, C. J. Lelliott, S. Tovar, W. Kimber, R. Gallego, S. Virtue, M. Blount, M. J. Vazquez, N. Finer, T. J. Powles, et al. Tamoxifen-Induced Anorexia Is Associated With Fatty Acid Synthase Inhibition in the Ventromedial Nucleus of the Hypothalamus and Accumulation of Malonyl-CoA. Diabetes, May 1, 2006; 55(5): 1327 - 1336. [Abstract] [Full Text] [PDF]

				C.-X. Yi, J. van der Vliet, J. Dai, G. Yin, L. Ru, and R. M. Buijs Ventromedial Arcuate Nucleus Communicates Peripheral Metabolic Information to the Suprachiasmatic Nucleus Endocrinology, January 1, 2006; 147(1): 283 - 294. [Abstract] [Full Text] [PDF]

				M. V. Kokoeva, H. Yin, and J. S. Flier Neurogenesis in the Hypothalamus of Adult Mice: Potential Role in Energy Balance Science, October 28, 2005; 310(5748): 679 - 683. [Abstract] [Full Text] [PDF]

				C. Sachot, S. Poole, and G. N Luheshi Circulating leptin mediates lipopolysaccharide-induced anorexia and fever in rats J. Physiol., November 15, 2004; 561(1): 263 - 272. [Abstract] [Full Text] [PDF]