|
 |
|
|||||||
|
|||||||||
Diabetes 53:1243-1252, 2004
© 2004 by the American Diabetes Association, Inc.
Adipose Tissue Expression of the Lipid Droplet–Associating Proteins S3-12 and Perilipin Is Controlled by Peroxisome Proliferator–Activated Receptor-
1 Institute for Nutrition Research, University of Oslo, Oslo, Norway
2 Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, INSERM, Illkirch, France
In a systematic search for peroxisome proliferator–activated receptor-
(PPAR-) target genes, we identified S3-12 and perilipin as novel direct PPAR- target genes. Together with adipophilin and tail-interacting protein of 47 kDa, these genes are lipid droplet–associating proteins with distinct expression pattern but overlapping expression in adipose tissue. The expression of S3-12 and perilipin is tightly correlated to the expression and activation of PPAR- in adipocytes, and promoter characterization revealed that the S3-12 and the perilipin promoters contain three and one evolutionarily conserved PPAR response elements, respectively. We furthermore demonstrate that the expression of S3-12 and perilipin is reduced in obese compared with lean Zucker rats, whereas the expression of adipophilin is increased. Others have shown that perilipin is an essential factor in the hormonal regulation of lipolysis of stored triglycerides within adipose tissue. The direct regulation of perilipin and S3-12 by PPAR- therefore is likely to be an important mediator of the in vivo effects of prolonged treatment with PPAR- activators: insulin sensitization, fatty acid trapping in adipose tissue, reduced basal adipose lipolysis, and weight gain.
Address correspondencereprint requests to Hilde Irene Nebb, Institute for Nutrition Research, University of Oslo, P.O. Box 1046 Blindern, N-0316 Oslo, Norway. E-mail: h.i.nebb{at}basalmed.uio.no
CiteULike 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  W. T. Schaiff, F. F. Knapp Jr., Y. Barak, T. Biron-Shental, D. M. Nelson, and Y. Sadovsky Ligand-Activated Peroxisome Proliferator Activated Receptor {gamma} Alters Placental Morphology and Placental Fatty Acid Uptake in Mice Endocrinology, August 1, 2007; 148(8): 3625 - 3634. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Laurencikiene, V. van Harmelen, E. Arvidsson Nordstrom, A. Dicker, L. Blomqvist, E. Naslund, D. Langin, P. Arner, and M. Ryden NF-{kappa}B is important for TNF-{alpha}-induced lipolysis in human adipocytes J. Lipid Res., May 1, 2007; 48(5): 1069 - 1077. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. E. Wolins, B. K. Quaynor, J. R. Skinner, A. Tzekov, M. A. Croce, M. C. Gropler, V. Varma, A. Yao-Borengasser, N. Rasouli, P. A. Kern, et al. OXPAT/PAT-1 Is a PPAR-Induced Lipid Droplet Protein That Promotes Fatty Acid Utilization Diabetes, December 1, 2006; 55(12): 3418 - 3428. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J E Digby, J Chen, J Y Tang, H Lehnert, R N Matthews, and H S Randeva Orexin receptor expression in human adipose tissue: effects of orexin-A and orexin-B. J. Endocrinol., October 1, 2006; 191(1): 129 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yamaguchi, S. Matsushita, K. Motojima, F. Hirose, and T. Osumi MLDP, a Novel PAT Family Protein Localized to Lipid Droplets and Enriched in the Heart, Is Regulated by Peroxisome Proliferator-activated Receptor {alpha} J. Biol. Chem., May 19, 2006; 281(20): 14232 - 14240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. T. Dalen, S. M. Ulven, B. M. Arntsen, K. Solaas, and H. I. Nebb PPAR{alpha} activators and fasting induce the expression of adipose differentiation-related protein in liver J. Lipid Res., May 1, 2006; 47(5): 931 - 943. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. R. Tobin, N. K. Harsem, K. T. Dalen, A. C. Staff, H. I. Nebb, and A. K. Duttaroy Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line J. Lipid Res., April 1, 2006; 47(4): 815 - 823. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zuo, L. Qiang, and S. R. Farmer Activation of CCAAT/Enhancer-binding Protein (C/EBP) {alpha} Expression by C/EBPbeta during Adipogenesis Requires a Peroxisome Proliferator-activated Receptor-{gamma}-associated Repression of HDAC1 at the C/ebp{alpha} Gene Promoter J. Biol. Chem., March 24, 2006; 281(12): 7960 - 7967. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Shimizu, Mst. H. Akter, Y. Emi, R. Sato, T. Yamaguchi, F. Hirose, and T. Osumi Peroxisome Proliferator-Activated Receptor Subtypes Differentially Cooperate with Other Transcription Factors in Selective Transactivation of the Perilipin/PEX11{alpha} Gene Pair. J. Biochem., March 1, 2006; 139(3): 563 - 573. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. H.-J. Chang, L. Li, A. Paul, S. Taniguchi, V. Nannegari, W. C. Heird, and L. Chan Protection against Fatty Liver but Normal Adipogenesis in Mice Lacking Adipose Differentiation-Related Protein Mol. Cell. Biol., February 1, 2006; 26(3): 1063 - 1076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chung, J. M. Brown, M. B. Sandberg, and M. McIntosh Trans-10,cis-12 CLA increases adipocyte lipolysis and alters lipid droplet-associated proteins: role of mTOR and ERK signaling J. Lipid Res., May 1, 2005; 46(5): 885 - 895. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Diabetes | Diabetes Care | Clinical Diabetes | Diabetes Spectrum |