|
 |
|
|||||||
|
|||||||||
Diabetes 53:1399-1402, 2004
© 2004 by the American Diabetes Association, Inc.
Brief Genetics Report |
Genome-Wide Linkage to Chromosome 6 for Waist Circumference in the Framingham Heart Study
1 National Heart, Lung, and Blood Institute’s Framingham Heart Study, Bethesda, Maryland
2 National Heart, Lung, and Blood Institute, Bethesda, Maryland
3 Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
4 Department of Neurology, Boston University School of Medicine, Boston, Massachusetts
5 Department of Medicine, Boston University School of Medicine, Boston, Massachusetts
6 Boston University Statistics and Consulting Unit, Boston, Massachusetts
7 Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts
While several loci for BMI have been identified, it is not known whether genes underlie the process of regional fat deposition. We sought to test whether waist circumference, a measure of central adiposity, contains a genetic component. Variance components linkage analysis was performed on 330 families from the Framingham Heart Study original and offspring cohorts, using a 10-cM genome-wide linkage analysis. Overall, 2,086 subjects (51% women), mean age 48 years, were available for analysis. The overall heritability of waist circumference was 0.41. The maximum logarithm of odds (LOD) score in the full dataset was 3.3 on chromosome 6 at marker D6S1009; when subjects were limited to those aged <60 years, the peak LOD score was 3.7 at the same location. Substantial evidence exists for linkage to waist circumference, a measure of central adiposity. Potential candidate genes include ESR1, OPRM1, and NMBR. Further research is necessary to understand the genes involved in central adiposity.
Address correspondence and reprint requests to Caroline S. Fox, MD, MPH, 73 Mt. Wayte Ave., Suite #2, Framingham, MA 01702. E-mail: foxca{at}nhlbi.nih.gov
CiteULike 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  C. J. Gallagher, C. D. Langefeld, C. J. Gordon, J. K. Campbell, J. C. Mychalecky, M. Bryer-Ash, S. S. Rich, D. W. Bowden, and M. M. Sale Association of the Estrogen Receptor-{alpha} Gene With the Metabolic Syndrome and Its Component Traits in African-American Families: The Insulin Resistance Atherosclerosis Family Study Diabetes, August 1, 2007; 56(8): 2135 - 2141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Yang, T. Kelly, and J. He Genetic Epidemiology of Obesity Epidemiol. Rev., June 12, 2007; (2007) mxm004v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Murabito, C.-Y. Guo, C. S. Fox, and R. B. D'Agostino Heritability of the Ankle-Brachial Index: The Framingham Offspring Study Am. J. Epidemiol., November 15, 2006; 164(10): 963 - 968. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Fox, Q. Yang, L. A. Cupples, C.-Y. Guo, L. D. Atwood, J. M. Murabito, D. Levy, M. E. Mendelsohn, D. E. Housman, and A. M. Shearman Sex-Specific Association between Estrogen Receptor-{alpha} Gene Variation and Measures of Adiposity: The Framingham Heart Study J. Clin. Endocrinol. Metab., November 1, 2005; 90(11): 6257 - 6262. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Yang, C.-Q. Lai, L. Parnell, L. A. Cupples, X. Adiconis, Y. Zhu, P. W. F. Wilson, D. E. Housman, A. M. Shearman, R. B. D'Agostino, et al. Genome-wide linkage analyses and candidate gene fine mapping for HDL3 cholesterol: the Framingham Study J. Lipid Res., July 1, 2005; 46(7): 1416 - 1425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Fox, N. L. Heard-Costa, R. S. Vasan, J. M. Murabito, R. B. D'Agostino Sr., and L. D. Atwood Genomewide Linkage Analysis of Weight Change in the Framingham Heart Study J. Clin. Endocrinol. Metab., June 1, 2005; 90(6): 3197 - 3201. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Diabetes | Diabetes Care | Clinical Diabetes | Diabetes Spectrum |