Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lakka, T. A.
Right arrow Articles by Bouchard, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lakka, T. A.
Right arrow Articles by Bouchard, C.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes 53:1603-1608, 2004
© 2004 by the American Diabetes Association, Inc.

Brief Genetics Report

Leptin and Leptin Receptor Gene Polymorphisms and Changes in Glucose Homeostasis in Response to Regular Exercise in Nondiabetic Individuals

The HERITAGE Family Study

Timo A. Lakka1,2, Tuomo Rankinen1, S. John Weisnagel3, Yvon C. Chagnon4, Hanna-Maaria Lakka1, Olavi Ukkola5, Normand Boulé3, Treva Rice6, Arthur S. Leon7, James S. Skinner8, Jack H. Wilmore9, D.C. Rao6,10,11, Richard Bergman12, and Claude Bouchard1

1 Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana
2 Kuopio Research Institute of Exercise Medicine, University of Kuopio, Kuopio, Finland
3 Department of Social & Preventive Medicine, Laval University, Ste-Foy, Québec, Canada
4 Laval University, Ste-Foy, Québec, Canada
5 Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
6 Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri
7 School of Kinesiology and Leisure Studies, University of Minnesota, Minneapolis, Minnesota
8 Department of Kinesiology, Indiana University, Bloomington, Indiana
9 Department of Health and Kinesiology, Texas A & M University, College Station, Texas
10 Department of Genetics, Washington University School of Medicine, St. Louis, Missouri
11 Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri
12 Keck School of Medicine, University of Southern California, Los Angeles, California

We recently reported that a genomic region close to the leptin locus was linked to fasting insulin response to exercise training in nondiabetic white subjects. We tested the hypothesis that common exonic variants in the leptin (LEP) and leptin receptor (LEPR) genes modify the effects of regular physical activity on glucose homeostasis in nondiabetic whites (n = 397) and blacks (n = 143). In whites, exercise increased insulin sensitivity index (P = 0.041) and disposition index (P = 0.046) in the LEPR 109R allele carriers but not in the K109K homozygotes, increased glucose disappearance index more in the R109R homozygotes than in the K109 allele carriers (P = 0.039), and decreased fasting glucose only in the 109R allele carriers (P = 0.018). We also found an interaction between the LEP A19G and LEPR K109R polymorphisms on the change in fasting insulin in whites (P = 0.010). The association between the LEP A19G polymorphism and the change in insulin was evident only in the LEPR 109R carriers (P = 0.019). The decrease in insulin was strongest in the LEP A19A homozygotes who carried the LEPR 109R allele. Similar interaction was observed in blacks (P = 0.046). Variations in the LEP and LEPR genes are associated with the magnitude of the effects of regular exercise on glucose homeostasis in nondiabetic individuals.

Address correspondence and reprint requests to Timo A. Lakka, Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd., Baton Rouge, LA 70808-4124. E-mail: lakkat{at}pbrc.edu


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Eur Heart JHome page
T. A. Lakka, H.-M. Lakka, T. Rankinen, A. S. Leon, D.C. Rao, J. S. Skinner, J. H. Wilmore, and C. Bouchard
Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study
Eur. Heart J., October 1, 2005; 26(19): 2018 - 2025.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
Y. Ning, M.A. Williams, C.L. Butler, M. Muy-Rivera, I.O. Frederick, and T.K. Sorensen
Maternal recreational physical activity is associated with plasma leptin concentrations in early pregnancy
Hum. Reprod., February 1, 2005; 20(2): 382 - 389.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
N. G. Boule, S. J. Weisnagel, T. A. Lakka, A. Tremblay, R. N. Bergman, T. Rankinen, A. S. Leon, J. S. Skinner, J. H. Wilmore, D.C. Rao, et al.
Effects of Exercise Training on Glucose Homeostasis: The HERITAGE Family Study
Diabetes Care, January 1, 2005; 28(1): 108 - 114.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. S. Rich, D. W. Bowden, S. M. Haffner, J. M. Norris, M. F. Saad, B. D. Mitchell, J. I. Rotter, C. D. Langefeld, C. C. Hedrick, L. E. Wagenknecht, et al.
A Genome Scan for Fasting Insulin and Fasting Glucose Identifies a Quantitative Trait Locus on Chromosome 17p: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study
Diabetes, January 1, 2005; 54(1): 290 - 295.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2004 by the American Diabetes Association.