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Diabetes 53:1609-1613, 2004
© 2004 by the American Diabetes Association, Inc.

Brief Genetics Report

Genome-wide Scan for Type 2 Diabetes Loci in Hong Kong Chinese and Confirmation of a Susceptibility Locus on Chromosome 1q21-q25

Maggie C.Y. Ng1,2, Wing-Yee So1, Nancy J. Cox3,4, Vincent K.L. Lam1, Clive S. Cockram1, Julian A.J.H. Critchley1,{dagger}, Graeme I. Bell2,3,4, and Juliana C.N. Chan1

1 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
2 Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois
3 Department of Human Genetics, University of Chicago, Chicago, Illinois
4 Department of Medicine, University of Chicago, Chicago, Illinois

We conducted an autosomal genome scan to map loci for type 2 diabetes in a Hong Kong Chinese population. We studied 64 families, segregating type 2 diabetes, of which 57 had at least one member with an age at diagnosis of <=40 years. These families included a total of 126 affected sibpairs and 4 other affected relative pairs. Nonparametric linkage analysis revealed seven regions showing nominal evidence for linkage with type 2 diabetes (logarithm of odds [LOD] >0.59, Ppointwise < 0.05): chromosome 1 at 173.9 cM (LOD = 3.09), chromosome 3 at 26.3 cM (LOD = 1.27), chromosome 4 at 135.3 cM (LOD = 2.63), chromosome 5 at 139.3 cM (LOD = 0.84), chromosome 6 at 178.9 cM (LOD = 1.91), chromosome 12 at 48.7 cM (LOD = 1.99), and chromosome 18 at 28.1 cM (LOD = 1.00). Simulation studies showed genome-wide significant evidence for linkage of the chromosome 1 region (Pgenome-wide = 0.036). We have confirmed the results of previous studies for the presence of a susceptibility locus on chromosome 1q21-q25 (173.9 cM) and suggest the locations of other loci that may contribute to the development of type 2 diabetes in Hong Kong Chinese.

Address correspondence and reprint requests to Dr. Maggie C.Y. Ng, Howard Hughes Medical Institute, University of Chicago, 5841 S. Maryland Ave., MC1028, Chicago, IL 60637. E-mail: maggieng{at}uchicago.edu


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Copyright © 2004 by the American Diabetes Association.