Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Blake, D. R.
Right arrow Articles by Nathan, D. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Blake, D. R.
Right arrow Articles by Nathan, D. M.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes 53:2095-2100, 2004
© 2004 by the American Diabetes Association, Inc.

Impaired Glucose Tolerance, but not Impaired Fasting Glucose, Is Associated With Increased Levels of Coronary Heart Disease Risk Factors

Results From the Baltimore Longitudinal Study on Aging

Deirdre R. Blake1, James B. Meigs1,2, Denis C. Muller3, Samer S. Najjar3, Reubin Andres3, and David M. Nathan1

1 Diabetes Unit, Diabetes Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
2 General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
3 National Institute on Aging, Baltimore, Maryland

Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) identify individuals at high risk for progression to diabetes. Whether IFG and IGT have comparable coronary heart disease (CHD) risk factor profiles, independent of their progression to diabetes, is unclear. We determined CHD risk factor levels in 937 nondiabetic individuals at baseline and biannually over a mean follow-up period of 9.5 years. Subjects had no known CHD at baseline and had ≥2 (mean 4.2) oral glucose tolerance tests during follow-up. We classified glucose tolerance categories using American Diabetes Association diagnostic criteria or modified criteria that redefined IFG as 100–126 mg/dl, creating a similar baseline prevalence of IFG and IGT. Subjects who developed diabetes during follow-up were excluded from our analysis. Baseline CHD risk factors were similar in subjects with normal glucose tolerance (NGT) and IFG, but significantly more atherogenic in those with IGT or IFG + IGT. These findings were unchanged when the modified criteria were used, suggesting that IGT is phenotypically different from IFG and is associated with increased levels of CHD risk factors. Subjects with isolated IFG had similar levels of CHD risk factors as NGT subjects, even when IFG was redefined with a lower threshold. Although CHD risk factors were increased in the IGT group, the incidence of CHD events was not significantly different among groups, perhaps owing to the limited number of events. The differences in CHD risk factors among prediabetic groups may have clinical implications for screening strategies and CHD risk stratification of individuals with IFG and IGT.

Address correspondence and reprint requests to David M. Nathan, MD, Diabetes Unit, Massachusetts General Hospital, Bulfinch 408, Boston, MA 02114. E-mail: dnathan{at}partners.org


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Diabetes CareHome page
J. L. Kitzmiller, L. Dang-Kilduff, and M. M. Taslimi
Gestational Diabetes After Delivery: Short-term management and long-term risks
Diabetes Care, July 1, 2007; 30(Supplement_2): S225 - S235.
[Full Text] [PDF]

Home page
 Diabetes CareHome page
D. M. Nathan, M. B. Davidson, R. A. DeFronzo, R. J. Heine, R. R. Henry, R. Pratley, and B. Zinman
Impaired Fasting Glucose and Impaired Glucose Tolerance: Implications for care
Diabetes Care, March 1, 2007; 30(3): 753 - 759.
[Full Text] [PDF]

Home page
 Diabetes CareHome page
J. S. Pankow, D. K. Kwan, B. B. Duncan, M. I. Schmidt, D. J. Couper, S. Golden, and C. M. Ballantyne
Cardiometabolic Risk in Impaired Fasting Glucose and Impaired Glucose Tolerance: The Atherosclerosis Risk in Communities Study
Diabetes Care, February 1, 2007; 30(2): 325 - 331.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
R. E. van Genugten, K. M. Utzschneider, J. Tong, F. Gerchman, S. Zraika, J. Udayasankar, E. J. Boyko, W. Y. Fujimoto, S. E. Kahn, and and the American Diabetes Association GENNID Study
Effects of Sex and Hormone Replacement Therapy Use on the Prevalence of Isolated Impaired Fasting Glucose and Isolated Impaired Glucose Tolerance in Subjects With a Family History of Type 2 Diabetes
Diabetes, December 1, 2006; 55(12): 3529 - 3535.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
D.-Y. Hu, C.-Y. Pan, J.-M. Yu, and for the China Heart Survey Group
The relationship between coronary artery disease and abnormal glucose regulation in China: the China Heart Survey
Eur. Heart J., November 1, 2006; 27(21): 2573 - 2579.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
S. Morita, S. Kasayama, M. Otsuki, N. Asanuma, H. Saito, M. Mukai, and M. Koga
Atherosclerotic risk factors in Japanese subjects with isolated impaired fasting glucose and those with isolated impaired glucose tolerance according to 1997 and 2003 american diabetes association criteria.
Diabetes Care, September 1, 2006; 29(9): 2123 - 2126.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. K. Parsons, H. B. Carter, A. W. Partin, B. G. Windham, E. J. Metter, L. Ferrucci, P. Landis, and E. A. Platz
Metabolic Factors Associated with Benign Prostatic Hyperplasia
J. Clin. Endocrinol. Metab., July 1, 2006; 91(7): 2562 - 2568.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
C. Nielson, T. Lange, and N. Hadjokas
Blood Glucose and Coronary Artery Disease in Nondiabetic Patients
Diabetes Care, May 1, 2006; 29(5): 998 - 1001.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
K. Matz, K. Keresztes, C. Tatschl, M. Nowotny, A. Dachenhausen, M. Brainin, and J. Tuomilehto
Disorders of Glucose Metabolism in Acute Stroke Patients: An underrecognized problem
Diabetes Care, April 1, 2006; 29(4): 792 - 797.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
F. J. Novoa, M. Boronat, P. Saavedra, J. M. Diaz-Cremades, V. F. Varillas, F. La Roche, M. P. Alberiche, and A. Carrillo
Differences in Cardiovascular Risk Factors, Insulin Resistance, and Insulin Secretion in Individuals With Normal Glucose Tolerance and in Subjects With Impaired Glucose Regulation: The Telde Study
Diabetes Care, October 1, 2005; 28(10): 2388 - 2393.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
O. Vaccaro and G. Riccardi
Changing the Definition of Impaired Fasting Glucose: Impact on the classification of individuals and risk definition
Diabetes Care, July 1, 2005; 28(7): 1786 - 1788.
[Abstract] [Full Text] [PDF]

Home page
 DOC NewsHome page
Impaired Glucose Tolerance Linked to CHD
DOC News, October 1, 2004; 1(2): 22 - 22.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2004 by the American Diabetes Association.