HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bennett, A. J. Articles by McCarthy, M. I. Search for Related Content PubMed PubMed Citation Articles by Bennett, A. J. Articles by McCarthy, M. I. Social Bookmarking                What's this?

Variation at the Insulin Gene VNTR (Variable Number Tandem Repeat) Polymorphism and Early Growth

Studies in a Large Finnish Birth Cohort

¹ Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, U.K
² Department of Epidemiology and Public Health, Imperial College (St. Mary’s Campus), London, U.K
³ Department of Clinical Chemistry, University of Oulu, Oulu, Finland
⁴ Department of Obstetrics and Gynaecology, University of Oulu, Oulu, Finland
⁵ Department of Public Health Science and General Practice, University of Oulu, Oulu, Finland
⁶ Wellcome Trust Centre for Human Genetics, Churchill Hospital, Oxford, U.K

Variation at the insulin gene (INS-)VNTR (variable number of tandem repeats) minisatellite polymorphism has been reported to be associated with both early growth and adult metabolic phenotypes. However, the samples studied have been small and the relationship between INS-VNTR variation and parameters of early growth inconsistent, with four previous studies producing conflicting results. We have studied the relationship between INS-VNTR class (measured by genotyping the nearby –23HphI variant with which it is in tight linkage disequilibrium) and early growth in 5,646 members of the Northern Finnish Birth Cohort of 1966. Comparing class III homozygotes with other genotypes using multivariate linear regression analysis, we found no significant associations with any early growth measure (birth weight, birth length, ponderal index, and head circumference at 1 year), even after stratifying subjects by growth trajectory during infancy and/or birth order. For example, among infants with limited postnatal growth realignment (n = 2,470), class III/III infants were no heavier at birth (difference [±SE] in the means [fully adjusted], 58 ± 51 g; P = 0.26) than class I/– infants. No significant associations were detected following reanalysis with an additive model (for example, for birth weight, ß = 20 g [95% CI –3 to 44], P = 0.09). Studies of this large population-based cohort have failed to generate convincing evidence that INS-VNTR variation influences early growth.

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				D. B. Dunger, C. J. Petry, and K. K. Ong Genetics of Size at Birth Diabetes Care, July 1, 2007; 30(Supplement_2): S150 - S155. [Full Text] [PDF]

				C. W. Hay and K. Docherty Comparative Analysis of Insulin Gene Promoters: Implications for Diabetes Research Diabetes, December 1, 2006; 55(12): 3201 - 3213. [Abstract] [Full Text] [PDF]

				E. Landmann, F. Geller, J. Schilling, S. Rudloff, E. Foeller-Gaudier, and L. Gortner Absence of the Wild-type Allele (192 Base Pairs) of a Polymorphism in the Promoter Region of the IGF-I Gene but Not a Polymorphism in the Insulin Gene Variable Number of Tandem Repeat Locus Is Associated With Accelerated Weight Gain in Infancy Pediatrics, December 1, 2006; 118(6): 2374 - 2379. [Abstract] [Full Text] [PDF]

				T.-A. Vu-Hong, E. Durand, S. Deghmoun, P. Boutin, D. Meyre, D. Chevenne, P. Czernichow, P. Froguel, and C. Levy-Marchal The INS VNTR Locus Does Not Associate with Smallness for Gestational Age (SGA) but Interacts with SGA to Increase Insulin Resistance in Young Adults J. Clin. Endocrinol. Metab., June 1, 2006; 91(6): 2437 - 2440. [Abstract] [Full Text] [PDF]

				S. Le Fur, C. Auffray, F. Letourneur, C. Cruaud, C. Le Stunff, and P. Bougneres Heterogeneity of class I INS VNTR allele association with insulin secretion in obese children Physiol Genomics, May 16, 2006; 25(3): 480 - 484. [Abstract] [Full Text] [PDF]

				M. S. Sandhu, B. Heude, E. H. Young, R. Luben, J. Luan, K.-T. Khaw, J. Todd, and N. J. Wareham INS VNTR Class Genotype and Indexes of Body Size and Obesity: Population-Based Studies of 7,999 Middle-Aged Men and Women Diabetes, September 1, 2005; 54(9): 2812 - 2815. [Abstract] [Full Text] [PDF]

				S. L. Fur, D. Fradin, P. Boileau, and P. Bougneres Association of Kir6.2 and INS VNTR variants with glucose homeostasis in young obese Physiol Genomics, August 11, 2005; 22(3): 398 - 401. [Abstract] [Full Text] [PDF]

				B. L. Powell, L. Haddad, A. Bennett, N. Gharani, U. Sovio, C. J. Groves, K. Rush, M. J. Goh, G. S. Conway, A. Ruokonen, et al. Analysis of Multiple Data Sets Reveals No Association between the Insulin Gene Variable Number Tandem Repeat Element and Polycystic Ovary Syndrome or Related Traits J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2988 - 2993. [Abstract] [Full Text] [PDF]