Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Marfella, R.
Right arrow Articles by Giugliano, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Marfella, R.
Right arrow Articles by Giugliano, D.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes 53:2383-2391, 2004
© 2004 by the American Diabetes Association, Inc.

Expression of Angiogenic Factors During Acute Coronary Syndromes in Human Type 2 Diabetes

Raffaele Marfella1,2, Katherine Esposito1,2, Francesco Nappo1, Mario Siniscalchi1, Ferdinando Carlo Sasso1, Michele Portoghese3, Maria Pia Di Marino4, Alfonso Baldi4, Salvatore Cuzzocrea5, Clara Di Filippo2,6, Guglielmo Barboso6, Feliciano Baldi4, Francesco Rossi2,6, Michele D’Amico2,6, and Dario Giugliano1,2

1 Department of Geriatrics and Metabolic Diseases, Section of Pathology, Second University of Naples, Naples, Italy
2 Centro di Eccellenza Cardiovascolare, Section of Pathology, Second University of Naples, Naples, Italy
3 Cardiovascular Surgery Unit, Hospital Sassari, Sassari, Italy
4 Department of Biochemistry, Section of Pathology, Second University of Naples, Naples, Italy
5 Department of Pharmacology, University of Messina, Messina, Italy
6 Department of Experimental Medicine, Section of Pathology, Second University of Naples, Naples, Italy

Inadequate angiogenic response to ischemia in diabetic myocardium could result in poor collateral formation. Because hypoxia-inducible factor (HIF)-1{alpha} is a transcriptional activator of vascular endothelial growth factor (VEGF) and is critical for initiating angiogenic responses to hypoxia, we investigated the expression of HIF-1{alpha} and VEGF in specimens of human heart tissue to elucidate the molecular responses to myocardial ischemia in diabetic patients during unstable angina. Moreover, accumulation of a marker of protein nitration nitrotyrosine, as well as the superoxide anion (O2–) levels and inducible nitric oxide synthase (iNOS), were evaluated. Ventricular biopsy specimens from 15 type 2 diabetic and 14 nondiabetic patients presenting with unstable angina (ischemic group) and from 20 patients (11 type 2 diabetic and 9 nondiabetic patients) who underwent coronary bypass surgery without angina within the preceding 10 days (control group) were collected during coronary bypass surgery. Nondiabetic patients had higher HIF-1{alpha} and VEGF expressions compared with diabetic patients (P < 0.001). As compared with nondiabetic specimens, diabetic specimens showed higher levels of both iNOS mRNA and protein levels (P < 0.001) associated with the highest tissue levels of nitrotyrosine and O2– (P < 0.001). Diabetes is associated with increased myocardial tissue levels of iNOS, O2–, and nitrotyrosine and reduced expression of myocardial angiogenesis factors during ischemia.

Address correspondence and reprint requests to Dott. Raffaele Marfella, Via Emilio Scaglione 141, 80145 Napoli, Italy. E-mail: raffaele.marfella{at}unina2.it


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Diabetes CareHome page
G. P. Fadini, S. Sartore, C. Agostini, and A. Avogaro
Significance of Endothelial Progenitor Cells in Subjects With Diabetes
Diabetes Care, May 1, 2007; 30(5): 1305 - 1313.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
R. Marfella, M. D'Amico, C. Di Filippo, A. Baldi, M. Siniscalchi, F. C. Sasso, M. Portoghese, O. Carbonara, B. Crescenzi, P. Sangiuolo, et al.
Increased Activity of the Ubiquitin-Proteasome System in Patients With Symptomatic Carotid Disease Is Associated With Enhanced Inflammation and May Destabilize the Atherosclerotic Plaque: Effects of Rosiglitazone Treatment
J. Am. Coll. Cardiol., June 20, 2006; 47(12): 2444 - 2455.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
R. Marfella, M. D'Amico, K. Esposito, A. Baldi, C. Di Filippo, M. Siniscalchi, F. C. Sasso, M. Portoghese, F. Cirillo, F. Cacciapuoti, et al.
The Ubiquitin-Proteasome System and Inflammatory Activity in Diabetic Atherosclerotic Plaques: Effects of Rosiglitazone Treatment
Diabetes, March 1, 2006; 55(3): 622 - 632.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
F. C. Sasso, D. Torella, O. Carbonara, G. M. Ellison, M. Torella, M. Scardone, C. Marra, R. Nasti, R. Marfella, D. Cozzolino, et al.
Increased Vascular Endothelial Growth Factor Expression But Impaired Vascular Endothelial Growth Factor Receptor Signaling in the Myocardium of Type 2 Diabetic Patients With Chronic Coronary Heart Disease
J. Am. Coll. Cardiol., September 6, 2005; 46(5): 827 - 834.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2004 by the American Diabetes Association.