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Diabetes 53:2473-2478, 2004
© 2004 by the American Diabetes Association, Inc.

Adiponectin and the Development of Type 2 Diabetes

The Atherosclerosis Risk in Communities Study

Bruce B. Duncan1,2, Maria Inês Schmidt1,2, James S. Pankow3, Heejung Bang4, David Couper4, Christie M. Ballantyne5, Ron C. Hoogeveen5, and Gerardo Heiss2

1 Graduate Studies Program in Epidemiology, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
2 Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina
3 Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota
4 Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill, North Carolina
5 Department of Medicine, Baylor College of Medicine, Houston, Texas

Adipocyte-derived secretory proteins have been increasingly linked to diabetes. To investigate whether adiponectin, a major adipocyte secretory protein, predicts diabetes, we conducted a case-cohort study representing the ~9-year experience of the 10,275 middle-aged, U.S. African-American and white participants of the Atherosclerosis Risk in Communities (ARIC) study. Adiponectin was measured on stored plasma of 581 incident diabetes case subjects and 572 noncase subjects. Overall hazard ratios (95% CIs) for developing diabetes, for those in the second, third, and fourth (versus the first) quartile of adiponectin were 0.57 (0.41–0.78), 0.39 (0.27–0.56), and 0.18 (0.11–0.27), respectively, after adjustment for age, sex, ethnicity, study center, parental history of diabetes, and hypertension and 0.72 (0.48–1.09), 0.67 (0.43–1.04), and 0.58 (0.34–0.99), respectively, after additional adjustment for BMI, waist-to-hip ratio, fasting glucose, insulin, and a score composed of six inflammation markers. The association was of similar magnitude in men and women and in whites and African Americans, but was absent in smokers and in those with a greater inflammation score (interaction P < 0.01 for each). In conclusion, in this community-based sample of U.S. adults, higher adiponectin levels were associated with a lower incidence of diabetes.

Address correspondence and reprint requests to Dr. Bruce B. Duncan, Graduate Studies Program in Epidemiology, UFRGS, Av. Luiz Manoel Gonzaga, 630/8, Porto Alegre, RS 90470-280 Brazil. E-mail: bbduncan{at}orion.ufrgs.br


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