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Diabetes 54:133-137, 2005
© 2005 by the American Diabetes Association, Inc.

Genetic Background Determines the Size and Structure of the Endocrine Pancreas

Troels Bock1,2, Bente Pakkenberg1, and Karsten Buschard2

1 Research Laboratory for Stereology and Neuroscience, Hovedstadens Sygehusfællesskab Bispebjerg Hospital, Copenhagen University Hospi-tal, Copenhagen, Denmark
2 Hovedstadens Sygehusfællesskab Bartholin Institute, Copenhagen University Hospital, Copenhagen, Denmark

Key parameters of the endocrine pancreas, such as islet number, islet mass, ß-cell mass, and {alpha}-cell mass, were studied in different strains of inbred mice to investigate the impact of genetic background on the size and structure of the endocrine pancreas. Six mice from each of seven different strains of inbred mice were included in the study. For all parameters investigated, there was a pronounced interstrain variation. ANCOVA showed that only mouse strain was statistically significant as an explanatory parameter for the number of islets. Mouse strain, body weight, and pancreas mass reached statistical significance as explanatory parameters for the islet mass, with mouse strain as the most significant predictor. These data show that genetic background is the most important predictor of both the number of islets and total islet volume. We also conclude that inbred mice could be a valuable resource to identify the genes responsible for the size and structure of the endocrine pancreas.

Address correspondence and reprint requests to Troels Bock, MD, PhD, Research Laboratory for Stereology and Neuroscience, H:S Bispebjerg Hospital, Copenhagen University Hospital, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark. E-mail: tbock{at}post12.tele.dk


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Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2005 by the American Diabetes Association.