HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Online-Only Appendix Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rich, S. S. Articles by Bergman, R. N. Search for Related Content PubMed PubMed Citation Articles by Rich, S. S. Articles by Bergman, R. N. Social Bookmarking                What's this?

A Genome Scan for Fasting Insulin and Fasting Glucose Identifies a Quantitative Trait Locus on Chromosome 17p

The Insulin Resistance Atherosclerosis Study (IRAS) Family Study

¹ Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina
² Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina
³ Department of Medicine, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas
⁴ Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado
⁵ Division of Clinical Epidemiology, University of California at Los Angeles, Los Angeles, California
⁶ Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland
⁷ Medical Genetics Institute, Steven Spielberg Pediatric Research Center, Cedars-Sinai Burns and Allen Research Institute, Los Angeles, California
⁸ Division of Endocrinology and Metabolism, University of Virginia Health Systems, Charlottesville, Virginia
⁹ Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California

Plasma insulin and glucose concentrations are important quantitative phenotypes related to diabetes and the metabolic syndrome. Reports purporting to identify quantitative trait loci (QTLs) that contribute to the variation in fasting insulin and glucose concentrations are discrepant. As part of the Insulin Resistance Atherosclerosis Study (IRAS) Family Study, a genome scan was performed in African-American (n = 42) and Hispanic (n = 90) extended families to identify regions that may contain positional candidate genes for fasting insulin and fasting glucose (n = 1,604 subjects). There was significant evidence for linkage of fasting insulin to the short arm of chromosome 17 (logarithm of odds [LOD] = 3.30; 54 cM between D17S1294 and D17S1299, P = 1.0 x 10^–4). The strongest evidence for linkage over all pedigrees for fasting glucose was also observed in this region (LOD = 1.44; 58 cM, P = 9.9 x 10^–3). The results of this study provide impetus for future positional cloning of QTLs regulating insulin and glucose levels. Identifying genes in these regions should provide insight into the nature of genetic factors regulating plasma glucose and insulin concentrations.

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				Y. W. Asmann, C. S. Stump, K. R. Short, J. M. Coenen-Schimke, Z. Guo, M. L. Bigelow, and K. S. Nair Skeletal Muscle Mitochondrial Functions, Mitochondrial DNA Copy Numbers, and Gene Transcript Profiles in Type 2 Diabetic and Nondiabetic Subjects at Equal Levels of Low or High Insulin and Euglycemia Diabetes, December 1, 2006; 55(12): 3309 - 3319. [Abstract] [Full Text] [PDF]