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Diabetes 54:3007-3014, 2005
© 2005 by the American Diabetes Association, Inc.

Analysis of Quantitative Lipid Traits in the Genetics of NIDDM (GENNID) Study

Alka Malhotra, Johanna K. Wolford, and the American Diabetes Association GENNID Study Group*

Translational Genomics Research Institute, Phoenix, Arizona

Coronary heart disease (CHD) is the leading cause of death among individuals with type 2 diabetes. Dyslipidemia contributes significantly to CHD in diabetic patients, in whom lipid abnormalities include hypertriglyceridemia, low HDL cholesterol, and increased levels of small, dense LDL particles. To identify genes for lipid-related traits, we performed genome-wide linkage analyses for levels of triglycerides and HDL, LDL, and total cholesterol in Caucasian, Hispanic, and African-American families from the Genetics of NIDDM (GENNID) study. Most lipid traits showed significant estimates of heritability (P < 0.001) with the exception of triglycerides and the triglyceride/HDL ratio in African Americans. Variance components analysis identified linkage on chromosome 3p12.1-3q13.31 for the triglyceride/HDL ratio (logarithm of odds [LOD] = 3.36) and triglyceride (LOD = 3.27) in Caucasian families. Statistically significant evidence for linkage was identified for the triglyceride/HDL ratio (LOD = 2.45) on 11p in Hispanic families in a region that showed suggestive evidence for linkage (LOD = 2.26) for triglycerides in this population. In African Americans, the strongest evidence for linkage (LOD = 2.26) was found on 19p13.2-19q13.42 for total cholesterol. Our findings provide strong support for previous reports of linkage for lipid-related traits, suggesting the presence of genes on 3p12.1-3q13.31, 11p15.4-11p11.3, and 19p13.2-19q13.42 that may influence traits underlying lipid abnormalities associated with type 2 diabetes.

Address correspondence and reprint requests to Johanna K. Wolford, Diabetes and Obesity Research Unit, Translational Genomics Research Institute, 445 N. 5th St., Phoenix, AZ 85004. E-mail: jwolford{at}tgen.org

Abbreviations: CAD, coronary artery disease; CHD, coronary heart disease; GENNID, Genetics of NIDDM; LOD, logarithm of odds


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Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2005 by the American Diabetes Association.