Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gibson, F.
Right arrow Articles by Froguel, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gibson, F.
Right arrow Articles by Froguel, P.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes 54:3040-3042, 2005
© 2005 by the American Diabetes Association, Inc.

Brief Genetics Reports

Common Polymorphisms in the USF1 Gene Are Not Associated With Type 2 Diabetes in French Caucasians

Fernando Gibson1, Serge Hercberg2, and Philippe Froguel1,3

1 Department of Genomic Medicine, Imperial College, Hammersmith Campus, London, U.K
2 Institut National de la Santé et de la Recherche Médicale, Unite de Surveillance et d’Epidemiologie Nutritionnelle, InVS/CNAM, Institut Scientifique et Technique de la Nutrition et de l’Alimentation/CNAM, Paris, France
3 Centre National de la Recherche Scientifique, Institut de Biologie de Lille, Institut Pasteur, Lille, France

Upstream transcription factor 1 (USF1) is a ubiquitously expressed transcription factor of the basic helix-loop-helix leucine zipper family that has been shown to regulate the expression of a raft of key genes involved in glucose and lipid metabolism. The USF1 gene is located at chromosome 1q22-q23, within the most consistently replicated type 2 diabetes susceptibility locus in the human genome. In this study, we have examined the contribution of eight common USF1 single nucleotide polymorphisms (SNPs) to type 2 diabetes susceptibility in the French Caucasian population. None of the USF1 SNPs genotyped, including two SNPs previously associated with familial combined hyperlipidemia (rs2073658 and rs3737787), showed evidence of association with type 2 diabetes. In addition, USF1 SNPs were not associated with plasma levels of glucose, triglycerides, total cholesterol, or apolipoproteins A1 or B in normoglycemic subjects. A total of four common USF1 haplotypes were identified, accounting for >99% of chromosomes. There was no significant difference in the USF1 haplotype distribution of the case and control subjects. In conclusion, we report here that we were unable to find any evidence to support the hypothesis that genetic variation in the USF1 gene makes a significant contribution to type 2 diabetes susceptibility in the French Caucasian population.

Address correspondence and reprint requests to Fernando Gibson, U557 INSERM and Unite de Surveillance et d’Epidemiologie Nutritionnelle, InVS/CNAM, Institut Scientifique et Technique de la Nutrition et de l’Alimentation/CNAM, Paris, France. E-mail: fernando.gibson{at}imperial.ac.uk

Abbreviations: FCHL, familial combined hyperlipidemia; LD, linkage disequilibrium; SNP, single nucleotide polymorphism; USF1, upstream transcription factor 1


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2005 by the American Diabetes Association.