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Diabetes 54:3326-3330, 2005
© 2005 by the American Diabetes Association, Inc.

Brief Genetics Reports

The Fatty Acid–Binding Protein-2 A54T Polymorphism Is Associated With Renal Disease in Patients With Type 2 Diabetes

Luis H. Canani1, Clarissa Capp1,2, Daniel P.K. Ng3,4,5, Serena G.L. Choo4, Ana Luiza Maia1, Gustavo B. Nabinger1, Kátia Santos6, Daisy Crispim6, Israel Roisemberg6, Andrzej S. Krolewski5, and Jorge L. Gross1

1 Endocrine Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
2 Department of Physiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
3 Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore
4 Centre for Molecular Epidemiology, National University of Singapore, Singapore
5 Section on Genetics and Epidemiology, Joslin Diabetes Center, Boston, Massachusetts
6 Department of Genetics, Federal University of Rio Grande do Sul, Porto Alegre, Brazil

The intestinal fatty–acid binding protein-2 (FABP2) gene codes a protein responsible for the absorption of long-chain fatty acids. To test whether FABP2 is a candidate gene for renal disease in patients with type 2 diabetes, a functional A54T polymorphism was genotyped in 1,042 Brazilians with type 2 diabetes. Patients were classified as having normoalbuminuria (urinary albumin excretion [UAE] <20 µg/min; n = 529), microalbuminuria (UAE 20–199 µg/min; n = 217), or proteinuria (UAE >199 µg/min; n = 160). Patients with end-stage renal disease (ESRD) (n = 136) were also included. The prevalence of the TT genotype was higher in patients with renal involvement compared with those with normoalbuminuria (odds ratio [95% CI] 2.4 [1.1–5.4]) following adjustment for type 2 diabetes duration, BMI, hypertension, A1C, and cholesterol levels. The risk was similar considering different stages of renal involvement. In a second independent patient sample (483 type 2 diabetic Caucasians residing in Massachusetts), a significant association was also observed between the TT genotype and proteinuria or ESRD (2.7 [1.0–7.3]; P = 0.048). This study thus provides evidence that FABP2 confers susceptibility to renal disease in type 2 diabetic patients.

Address correspondence and reprint requests to Jorge Luiz Gross, Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre, RS, Brazil, Rua Ramiro Barcelos 2350-Prédio 12-4° andar 90035-003 Porto Alegre, RS–Brazil. E-mail: jorgegross{at}terra.com.br

Abbreviations: ESRD, end-stage renal disease; FABP2, fatty acid–binding protein-2; IHD, ischemic heart disease; SNP, single nucleotide polymorphism; UAE, urinary albumin excretion


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Copyright © 2005 by the American Diabetes Association.