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Diabetes 54:3453-3457, 2005
© 2005 by the American Diabetes Association, Inc.

Brief Genetics Reports

Localization of Idd11 Is Not Associated With Thymus and NKT Cell Abnormalities in NOD Mice

Thomas C. Brodnicki1, Anne L. Fletcher2, Daniel G. Pellicci3, Stuart P. Berzins3, Peter McClive4, Fiona Quirk1, Kylie E. Webster1, Hamish S. Scott1, Richard L. Boyd2, Dale I. Godfrey3, and Grant Morahan5

1 Genetics and Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
2 Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria, Australia
3 Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
4 Department of Pediatrics, The Royal Children’s Hospital, Parkville, Victoria, Australia
5 Diabetes Research Centre, Western Australian Institute for Medical Research, Perth, Australia

Congenic mouse strains provide a unique resource for genetic dissection and biological characterization of chromosomal regions associated with diabetes progression in the nonobese diabetic (NOD) mouse. Idd11, a mouse diabetes susceptibility locus, was previously localized to a region on chromosome 4. Comparison of a panel of subcongenic NOD mouse strains with different intervals derived from the nondiabetic C57BL/6 (B6) strain now maps Idd11 to an ~8-Mb interval. B6-derived intervals protected congenic NOD mice from diabetes onset, even though lymphocytic infiltration of pancreatic islets was similar to that found in NOD mice. In addition, neither thymic structural irregularities nor NKT cell deficiencies were ameliorated in diabetes-resistant congenic NOD mice, indicating that Idd11 does not contribute to these abnormalities, which do not need to be corrected to prevent disease.

Address correspondencereprint requests to Thomas C. Brodnicki, The WalterEliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3050 Australia. E-mail: brodnicki{at}wehi.edu.au


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T. C. Brodnicki, K. O'Donnell, F. Quirk, D. M. Tarlinton, J. Rolf, V. Motta, N. Duarte, M. Lundholm, E. Berntman, M.-L. Bergman, et al.
Congenic Nonobese Diabetic Mouse Strains Fail to Confirm Linkage of a Marginal Zone B Lymphocyte Phenotype to the Idd11 Locus on Chromosome 4
J. Immunol., January 15, 2006; 176(2): 701 - 702.
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