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Diabetes 54:3573-3576, 2005
© 2005 by the American Diabetes Association, Inc.

Brief Genetics Reports

Patterns of Linkage Disequilibrium in the Type 2 Diabetes Gene Calpain-10

M. Geoffrey Hayes1,2, Laura del Bosque-Plata3, Takafumi Tsuchiya3, Craig L. Hanis4, Graeme I. Bell1,2,3, and Nancy J. Cox1,2

1 Department of Medicine, University of Chicago, Chicago, Illinois
2 Department of Human Genetics, University of Chicago, Chicago, Illinois
3 Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois
4 Human Genetics Center, University of Texas Health Sciences Center, Houston, Texas

We investigated the patterns and extent of linkage disequilibrium (LD) in the vicinity of the type 2 diabetes gene calapin-10 (CAPN10) in Mexican Americans, European Americans, African Americans, and Chinese Americans. We found that CAPN10 occurs within a single block of high LD and that LD decays rapidly outside of the gene. This reduces the likelihood that associations between CAPN10 polymorphisms and type 2 diabetes could be attributed to variation at some distance from CAPN10. We also consistently observed that cases have more extensive LD than control subjects and that cases from families with evidence for linkage have more extensive LD than cases from families without evidence for linkage. These observations further suggest that there are one or more relatively common alleles increasing risk of type 2 diabetes in this local region.

Address correspondence and reprint requests to Dr. Nancy J. Cox, Department of Human Genetics, University of Chicago, 920 E. 58th St., CLSC 507, Chicago, IL 60637. E-mail: ncox{at}bsd.uchicago.edu

Abbreviations: LD, linkage disequilibrium; NPL, nonparametric linkage; SNP, single nucleotide polymorphism


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Copyright © 2005 by the American Diabetes Association.