HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Harjutsalo, V. Articles by Tuomilehto, J. Search for Related Content PubMed PubMed Citation Articles by Harjutsalo, V. Articles by Tuomilehto, J. Social Bookmarking                What's this?

Cumulative Incidence of Type 1 Diabetes in 10,168 Siblings of Finnish Young-Onset Type 1 Diabetic Patients

¹ Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
² Endocrinology Center, Tartu, Estonia
³ Department of Public Health, University of Helsinki, Helsinki, Finland
⁴ South Ostrobotnia Central Hospital, Seinäjoki, Finland

The aims of our analysis were to obtain the empirical risk estimates for type 1 diabetes in the siblings of a Finnish population-based cohort of childhood-onset diabetic patients and search for demographic and other factors predicting the risk of type 1 diabetes in siblings. We defined the diabetes status of all siblings of all probands who are included in the nationwide register of Finnish cases for whom type 1 diabetes was diagnosed before age 18 years between 1965 and 1979. Siblings’ diabetes status was ascertained by a record search of nationwide registries through 2001, and the type of diabetes and date of its manifestation were obtained from medical records. The total number of person-years during the follow-up was 405,685. Of the 10,168 siblings at risk, 647 (6.4%) had been diagnosed with type 1 diabetes by 2001. The cumulative incidence of type 1 diabetes by ages 10, 20, 30, 40, and 50 years in all siblings was 1.5, 4.1, 5.5, 6.4, and 6.9%, respectively. A young age at diagnosis in the index case, paternal young-onset diabetes, male sex, and older parental age at delivery considerably increased the risk of type 1 diabetes for siblings. This large prospective family study of type 1 diabetes in siblings of childhood-onset diabetic patients provides reliable empirical estimates for the sibling recurrence risk.

Abbreviations: CDR, Central Drug Register; CPR, Central Population Registry; HDR, National Hospital Discharge Register

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M. Zoledziewska, C. Perra, V. Orru, L. Moi, P. Frongia, M. Congia, N. Bottini, and F. Cucca Further Evidence of a Primary, Causal Association of the PTPN22 620W Variant With Type 1 Diabetes Diabetes, January 1, 2008; 57(1): 229 - 234. [Abstract] [Full Text] [PDF]

				T. A. Aly, A. Ide, M. M. Jahromi, J. M. Barker, M. S. Fernando, S. R. Babu, L. Yu, D. Miao, H. A. Erlich, P. R. Fain, et al. Extreme genetic risk for type 1A diabetes PNAS, September 19, 2006; 103(38): 14074 - 14079. [Abstract] [Full Text] [PDF]