Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Appendix
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bagwell, A. M.
Right arrow Articles by Bowden, D. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bagwell, A. M.
Right arrow Articles by Bowden, D. W.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes 54:1185-1190, 2005
© 2005 by the American Diabetes Association, Inc.

Genetic Analysis of HNF4A Polymorphisms in Caucasian-American Type 2 Diabetes

Allison M. Bagwell1,2, Jennifer L. Bento2,3, Josyf C. Mychaleckyj2,4,5, Barry I. Freedman3, Carl D. Langefeld5, and Donald W. Bowden1,2,3,4

1 Molecular Genetics Program, Wake Forest University School of Medicine, Winston-Salem, North Carolina
2 Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina
3 Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina
4 Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina
5 Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina

Hepatocyte nuclear factor 4{alpha} (HNF4A), the gene for the maturity-onset diabetes of the young type 1 monogenic form of type 2 diabetes, is within the type 2 diabetes–linked region on chromosome 20q12-q13.1 and, consequently, is a positional candidate gene for type 2 diabetes in the general population. Previous studies have identified only a few rare coding mutations. However, recent studies suggest that single nucleotide polymorphisms (SNPs) located near the P2 (ß-cell) promoter of HNF4A are associated with diabetes susceptibility. In this study, we evaluated 23 SNPs spanning 111 kb including the HNF4A gene for association with type 2 diabetes in a collection of Caucasian type 2 diabetic patients with end-stage renal disease (n = 300) and control subjects (n = 310). None of the individual SNPs were associated with type 2 diabetes in this collection of case subjects (P values ranging from 0.06 to 0.99). However, haplotype analysis identifies significant differences between haplotype frequencies in type 2 diabetic case and control subjects (P = 0.013 to P < 0.001), with two uncommon "risk" haplotypes (2.4 and 2.2% of chromosomes) and two uncommon "protective" haplotypes (7.1 and 5.0% of chromosomes) accounting for the evidence of association. Our results suggest that type 2 diabetes linked to 20q12–13 is a heterogeneous disease in which different populations may have different type 2 diabetes susceptibility loci.

Address correspondence and reprint requests to Donald W. Bowden, Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157. E-mail: dbowden{at}wfubmc.edu


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 DiabetesHome page
J. Holmkvist, P. Almgren, V. Lyssenko, C. M. Lindgren, K.-F. Eriksson, B. Isomaa, T. Tuomi, P. Nilsson, and L. Groop
Common Variants in Maturity-Onset Diabetes of the Young Genes and Future Risk of Type 2 Diabetes
Diabetes, June 1, 2008; 57(6): 1738 - 1744.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. H. Black, T. E. Fingerlin, H. Allayee, W. Zhang, A. H. Xiang, E. Trigo, J. Hartiala, A. B. Lehtinen, S. M. Haffner, R. N. Bergman, et al.
Evidence of Interaction Between PPARG2 and HNF4A Contributing to Variation in Insulin Sensitivity in Mexican Americans
Diabetes, April 1, 2008; 57(4): 1048 - 1056.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. Johansson, H. Raeder, S. A Eide, K. Midthjell, K. Hveem, O. Sovik, A. Molven, and P. R. Njolstad
Studies in 3,523 Norwegians and Meta-Analysis in 11,571 Subjects Indicate That Variants in the Hepatocyte Nuclear Factor 4{alpha} (HNF4A) P2 Region Are Associated With Type 2 Diabetes in Scandinavians
Diabetes, December 1, 2007; 56(12): 3112 - 3117.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
R. M. Watanabe, M. H. Black, A. H. Xiang, H. Allayee, J. M. Lawrence, and T. A. Buchanan
Genetics of Gestational Diabetes Mellitus and Type 2 Diabetes
Diabetes Care, July 1, 2007; 30(Supplement_2): S134 - S140.
[Full Text] [PDF]

Home page
 DiabetesHome page
D. M. Lehman, D. K. Richardson, C. P. Jenkinson, K. J. Hunt, T. D. Dyer, R. J. Leach, R. Arya, H. E. Abboud, J. Blangero, R. Duggirala, et al.
P2 Promoter Variants of the Hepatocyte Nuclear Factor 4{alpha} Gene Are Associated With Type 2 Diabetes in Mexican Americans
Diabetes, February 1, 2007; 56(2): 513 - 517.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
L. L. Bonnycastle, C. J. Willer, K. N. Conneely, A. U. Jackson, C. P. Burrill, R. M. Watanabe, P. S. Chines, N. Narisu, L. J. Scott, S. T. Enloe, et al.
Common Variants in Maturity-Onset Diabetes of the Young Genes Contribute to Risk of Type 2 Diabetes in Finns
Diabetes, September 1, 2006; 55(9): 2534 - 2540.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
K. Hara, M. Horikoshi, H. Kitazato, C. Ito, M. Noda, J. Ohashi, P. Froguel, K. Tokunaga, K. Tobe, R. Nagai, et al.
Hepatocyte Nuclear Factor-4{alpha} P2 Promoter Haplotypes Are Associated With Type 2 Diabetes in the Japanese Population.
Diabetes, May 1, 2006; 55(5): 1260 - 1264.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2005 by the American Diabetes Association.