HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Stenström, G. Articles by Sundkvist, G. Search for Related Content PubMed PubMed Citation Articles by Stenström, G. Articles by Sundkvist, G. Social Bookmarking                What's this?

Latent Autoimmune Diabetes in Adults

Definition, Prevalence, ß-Cell Function, and Treatment

¹ Department of Medicine, Kungsbacka Hospital, Kungsbacka, Göteborg University, Göteborg, Sweden
² Division of Vascular Diseases, Department of Clinical Sciences Malmö, Lund University, Malmö University Hospital, Malmö, Sweden
³ Division of Diabetes Epidemiology and Neuropathy, Department of Clinical Sciences Malmö, Lund University, Malmö University Hospital, Malmö, Sweden

Latent autoimmune diabetes in adults (LADA) is a disorder in which, despite the presence of islet antibodies at diagnosis of diabetes, the progression of autoimmune ß-cell failure is slow. LADA patients are therefore not insulin requiring, at least during the first 6 months after diagnosis of diabetes. Among patients with phenotypic type 2 diabetes, LADA occurs in 10% of individuals older than 35 years and in 25% below that age. Prospective studies of ß-cell function show that LADA patients with multiple islet antibodies develop ß-cell failure within 5 years, whereas those with only GAD antibodies (GADAs) or only islet cell antibodies (ICAs) mostly develop ß-cell failure after 5 years. Even though it may take up to 12 years until ß-cell failure occurs in some patients, impairments in the ß-cell response to intravenous glucose and glucagon can be detected at diagnosis of diabetes. Consequently, LADA is not a latent disease; therefore, autoimmune diabetes in adults with slowly progressive ß-cell failure might be a more adequate concept. In agreement with proved impaired ß-cell function at diagnosis of diabetes, insulin is the treatment of choice.

Abbreviations: ADA, autoimmune diabetes in adults; GADA, GAD antibody; IA-2A; IA-2 antibody; ICA, islet cell antibody; LADA, latent autoimmune diabetes in adults

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				A. K. Steck and G. S. Eisenbarth Genetic Similarities Between Latent Autoimmune Diabetes and Type 1 and Type 2 Diabetes Diabetes, May 1, 2008; 57(5): 1160 - 1162. [Full Text] [PDF]

				A Mayer, N Fabien, M C Gutowski, V Dubois, L Gebuhrer, J Bienvenu, J Orgiazzi, and A M Madec Contrasting cellular and humoral autoimmunity associated with latent autoimmune diabetes in adults Eur. J. Endocrinol., July 1, 2007; 157(1): 53 - 61. [Abstract] [Full Text] [PDF]

				T. KOBAYASHI, S. TANAKA, N. HARII, K. AIDA, H. SHIMURA, M. OHMORI, M. KANESIGE, A. SHIMADA, and T. MARUYAMA Immunopathological and Genetic Features in Slowly Progressive Insulin-Dependent Diabetes Mellitus and Latent Autoimmune Diabetes in Adults Ann. N.Y. Acad. Sci., October 1, 2006; 1079(1): 60 - 66. [Abstract] [Full Text] [PDF]