HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rogner, U. C. Articles by Boitard, C. Search for Related Content PubMed PubMed Citation Articles by Rogner, U. C. Articles by Boitard, C. Social Bookmarking                What's this?

The Diabetes Type 1 Locus Idd6 Modulates Activity of CD4⁺CD25⁺ Regulatory T-Cells

¹ Unité de Génétique Moléculaire Murine, Centre National de Recherche (CNRS) Unité de Recherche Associée (URA) 2578, Institut Pasteur, Paris, France
² Hôpital Cochin St. Vincent de Paul, Paris, France

Address correspondence and reprint requests to Dr. U.C. Rogner, Génétique Moléculaire Murine, CNRS URA 2578, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France. E-mail: urogner{at}pasteur.fr

Abbreviations: FACS, fluorescence-activated cell sorter; IAA, insulin autoantibody; QTL, quantitative trait locus

The genetic locus Idd6 confers susceptibility to the spontaneous development of type 1 diabetes in the NOD mouse. Our studies on disease resistance of the congenic mouse strain NOD.C3H 6.VIII showed that Idd6 influences T-cell activities in the peripheral immune system and suggest that a major mechanism by which the Idd6 locus modifies diabetes development is via modulation of regulatory T-cell activities. Our transfer experiments using total splenocytes and purified T-cells demonstrated that the locus specifically controls the efficiency of disease protection mediated by the regulatory CD4⁺CD25⁺ T-cell subset. Our data also implicate the Idd6 locus in controlling the balance between infiltrating lymphocytes and antigen-presenting cells within the pancreatic islet.

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				D. Vallois, C. H. Grimm, P. Avner, C. Boitard, and U. C. Rogner The Type 1 Diabetes Locus Idd6 Controls TLR1 Expression J. Immunol., September 15, 2007; 179(6): 3896 - 3903. [Abstract] [Full Text] [PDF]

				M.-S. Hung, P. Avner, and U. C. Rogner Identification of the transcription factor ARNTL2 as a candidate gene for the type 1 diabetes locus Idd6 Hum. Mol. Genet., September 15, 2006; 15(18): 2732 - 2742. [Abstract] [Full Text] [PDF]