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Diabetes 55:2922-2927, 2006
DOI: 10.2337/db06-0302
© 2006 by the American Diabetes Association
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Brief Genetics Reports

The {alpha}-Adducin Gene Is Associated With Macrovascular Complications and Mortality in Patients With Type 2 Diabetes

Mojgan Yazdanpanah1, Fakhredin A. Sayed-Tabatabaei1, Albert Hofman1, Yurii S. Aulchenko1, Ben A. Oostra2, Bruno H.C. Stricker1, Huibert A.P. Pols1,3, Steven W.J. Lamberts3, Jacqueline C.M. Witteman1, Joop A.M.J.L. Janssen3, and Cornelia M. van Duijn1

1 Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, the Netherlands
2 Department of Clinical Genetic, Erasmus Medical Centre, Rotterdam, the Netherlands
3 Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, the Netherlands

Address correspondence and reprint requests to Cornelia M. van Duijn, Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, Netherlands. E-mail: c.vanduijn{at}erasmusmc.nl

Abbreviations: IMT, intima media thickness

We examined the association between {alpha}-adducin 1 (ADD1) gene polymorphism (Gly460Trp) with macrovascular complications and mortality in type 2 diabetes in a Caucasian population aged ≥55 years. The study was part of the Rotterdam Study, a prospective population-based cohort study. ADD1 polymorphism was determined in 6,471 participants, including 599 patients with type 2 diabetes at baseline. The prevalence of hypertension in type 2 diabetic patients was 2.57 times higher in ADD1 TT carriers compared with GG carriers (95% CI 1.05–6.32, P = 0.03). Homozygous T carriers also had a higher mean common carotid intima media thickness (IMT) compared with GG carriers (mean difference 0.05 mm, P for trend = 0.03). In diabetic patients with hypertension, the risk of mortality was 1.83 times higher in homozygous T carriers compared with the GG genotype group (95% CI 1.07–3.16, P = 0.03). The increased risk was only present among TT carriers who did not use antidiabetes medication (hazard ratio 2.18 [95% CI 1.12–4.24], P = 0.02). The results of this population-based cohort study suggest that the ADD1 gene contributes to the risk of hypertension and increases mean common carotid IMT in patients with type 2 diabetes. Furthermore, the study indicates that the ADD1 polymorphism could be useful in identifying hypertensive type 2 diabetic patients with a high risk of mortality.


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