Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Diabetes 55:3193-3196, 2006
DOI: 10.2337/db06-0414
© 2006 by the American Diabetes Association
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Online-Only Appendix
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by van Hove, E. C.
Right arrow Articles by 't Hart, L. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by van Hove, E. C.
Right arrow Articles by 't Hart, L. M.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Brief Genetics Reports

The HADHSC Gene Encoding Short-Chain L-3-Hydroxyacyl-CoA Dehydrogenase (SCHAD) and Type 2 Diabetes Susceptibility

The DAMAGE Study

Els C. van Hove1, Torben Hansen2, Jacqueline M. Dekker3, Erwin Reiling1, Giel Nijpels3, Torben Jørgensen4, Knut Borch-Johnsen2,5, Yasmin H. Hamid2, Robert J. Heine3, Oluf Pedersen2,5, J. Antonie Maassen1,3, and Leen M. 't Hart1

1 Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands
2 Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
3 Vrije Universiteit Medical Center, Institute for Research in Extramural Medicine, Amsterdam, the Netherlands
4 Research Center for Prevention and Health, Copenhagen County, Glostrup University Hospital, Glostrup, Denmark
5 Faculty of Health Science, Aarhus University, Aarhus, Denmark

Address correspondence and reprint requests to L.M. ‘t Hart, PhD, Leiden University Medical Center, Department of Molecular Cell Biology, Building 2, Room R2-005, Postal Zone S1-P, P.O. Box 9600, 2300 RC Leiden, Netherlands. E-mail: l.m.t_hart{at}lumc.nl

Abbreviations: NGT, normal glucose tolerance; SCHAD, short-chain L-3-hydroxyacyl-CoA dehydrogenase; SNP, single nucleotide polymorphism

The short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) protein is involved in the penultimate step of mitochondrial fatty acid oxidation. Previously, it has been shown that mutations in the corresponding gene (HADHSC) are associated with hyperinsulinism in infancy. The presumed function of the SCHAD enzyme in glucose-stimulated insulin secretion led us to the hypothesis that common variants in HADHSC on chromosome 4q22-26 might be associated with development of type 2 diabetes. In this study, we have performed a large-scale association study in four different cohorts from the Netherlands and Denmark (n = 7,365). Direct sequencing of HADHSC cDNA and databank analysis identified four tagging single nucleotide polymorphisms (SNPs) including one missense variant (P86L). Neither the SNPs nor haplotypes investigated were associated with the disease, enzyme function, or any relevant quantitative measure (all P > 0.1). The present study provides no evidence that the specific HADHSC variants or haplotypes examined do influence susceptibility to develop type 2 diabetes. We conclude that it is unlikely that variation in HADHSC plays a major role in the pathogenesis of type 2 diabetes in the examined cohorts.


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2006 by the American Diabetes Association.