HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Online-Only Appendix Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Vaxillaire, M. Articles by Froguel, P. Search for Related Content PubMed PubMed Citation Articles by Vaxillaire, M. Articles by Froguel, P. Social Bookmarking                What's this?

Genetic Analysis of ADIPOR1 and ADIPOR2 Candidate Polymorphisms for Type 2 Diabetes in the Caucasian Population

¹ Centre National de la Recherche Scientifique (CNRS) UMR 8090, Institute of Biology and Pasteur Institute, Lille, France
² Scientific and Technical Institute of Nutrition and Food (ISTNA-CNAM), Institut National de la Santé et de la Recherche Médicale (INSERM) U557, INRA U1125, Paris, France
³ Department of Endocrinology and Diabetology, Centre Hospitalier Sud Francilien, Corbeil-Essonnes, France
⁴ Section of Genomic Medicine, Imperial College Genome Centre, Hammersmith Campus, Imperial College London, London, U.K

Address correspondence and reprint requests to Dr. Martine Vaxillaire, CNRS 8090, Institut de Biologie, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019 Lille, France. E-mail: martine.vaxillaire{at}pasteur-lille.fr

Abbreviations: AdipoR1, adiponectin receptor 1; AdipoR2, adiponectin receptor 2; HWE, Hardy-Weinberg equilibrium; LD, linkage disequilibrium; MAF, minor allele frequency; SNP, single nucleotide polymorphism; UTR, untranslated region

Adiponectin is a metabolic link between adipose tissue and insulin action, mediating part of obesity-associated insulin resistance and type 2 diabetes. Two adiponectin receptors have been identified, and we investigated whether sequence variations in adiponectin receptor 1 (ADIPOR1) and adiponectin receptor 2 (ADIPOR2) genes could contribute to the genetic risk for type 2 diabetes in a case-control study of 1,498 Caucasian subjects. We sequenced the putative functional regions of the two genes in 48 subjects and selected single nucleotide polymorphisms (SNPs) from the public database. Five SNPs in ADIPOR1 and 12 in ADIPOR2 were tested for association with type 2 diabetes. No SNP of ADIPOR1 showed association in any of the samples from the French population. In contrast, three SNPs of ADIPOR2 showed nominal evidence for association with type 2 diabetes before correction for multiple testing (odds ratio [OR] 1.29–1.37, P = 0.034–0.014); only rs767870, located in intron 6, was replicated in an additional diabetes dataset (n = 636, OR 1.29, P = 0.020) with significant allelic association from the overall meta-analysis of 2,876 subjects (adjusted OR 1.25 [95% CI 1.07–1.45], P = 0.0051). In conclusion, our data suggest a modest contribution of ADIPOR2 variants in diabetes risk in the French population.

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M. Vaxillaire, J. Veslot, C. Dina, C. Proenca, S. Cauchi, G. Charpentier, J. Tichet, F. Fumeron, M. Marre, D. Meyre, et al. Impact of Common Type 2 Diabetes Risk Polymorphisms in the DESIR Prospective Study Diabetes, January 1, 2008; 57(1): 244 - 254. [Abstract] [Full Text] [PDF]

				H. Storgaard, P. Poulsen, C. Ling, L. Groop, and A. A. Vaag Relationships of Plasma Adiponectin Level and Adiponectin Receptors 1 and 2 Gene Expression to Insulin Sensitivity and Glucose and Fat Metabolism in Monozygotic and Dizygotic Twins J. Clin. Endocrinol. Metab., July 1, 2007; 92(7): 2835 - 2839. [Abstract] [Full Text] [PDF]

				L. Qi, A. Doria, E. Giorgi, and F. B. Hu Variations in Adiponectin Receptor Genes and Susceptibility to Type 2 Diabetes in Women: A Tagging-Single Nucleotide Polymorphism Haplotype Analysis Diabetes, June 1, 2007; 56(6): 1586 - 1591. [Abstract] [Full Text] [PDF]

				C. Menzaghi, V. Trischitta, and A. Doria Genetic Influences of Adiponectin on Insulin Resistance, Type 2 Diabetes, and Cardiovascular Disease Diabetes, May 1, 2007; 56(5): 1198 - 1209. [Abstract] [Full Text] [PDF]

				W. Li, J. Tonelli, P. Kishore, R. Owen, E. Goodman, P. E. Scherer, and M. Hawkins Insulin-sensitizing effects of thiazolidinediones are not linked to adiponectin receptor expression in human fat or muscle Am J Physiol Endocrinol Metab, May 1, 2007; 292(5): E1301 - E1307. [Abstract] [Full Text] [PDF]

				M. Bjursell, A. Ahnmark, M. Bohlooly-Y, L. William-Olsson, M. Rhedin, X.-R. Peng, K. Ploj, A.-K. Gerdin, G. Arnerup, A. Elmgren, et al. Opposing Effects of Adiponectin Receptors 1 and 2 on Energy Metabolism Diabetes, March 1, 2007; 56(3): 583 - 593. [Abstract] [Full Text] [PDF]

				Y. Liu, M. D. Michael, S. Kash, W. R. Bensch, B. P. Monia, S. F. Murray, K. A. Otto, S. K. Syed, S. Bhanot, K. W. Sloop, et al. Deficiency of Adiponectin Receptor 2 Reduces Diet-Induced Insulin Resistance but Promotes Type 2 Diabetes Endocrinology, February 1, 2007; 148(2): 683 - 692. [Abstract] [Full Text] [PDF]