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Diabetes 55:1879-1883, 2006
DOI: 10.2337/db05-1495
© 2006 by the American Diabetes Association
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Brief Genetics Reports

Linkage but Not Association of Calpain-10 to Type 2 Diabetes Replicated in Northern Sweden

Elisabet Einarsdottir1, Sofia Mayans1, Karin Ruikka2, Stefan A. Escher1, Petter Lindgren1, Åsa Ågren3, Mats Eliasson2,3, and Dan Holmberg1

1 Division of Medical and Clinical Genetics, Department of Medical Biosciences, Umeå University, Umeå, Sweden
2 Department of Medicine, Sunderby Hospital, Umeå, Sweden
3 Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

Address correspondence and reprint requests to Dr. Dan Holmberg, Department of Medical Biosciences, Division of Medical and Clinical Genetics, Umeå University, SE-901 87 Umeå, Sweden. E-mail: dan.holmberg{at}medbio.umu.se

Abbreviations: IGT, impaired glucose tolerance; OGTT, oral glucose tolerance test; SNP, single nucleotide polymorphism

We present data from a genome-wide scan identifying genetic factors conferring susceptibility to type 2 diabetes. The linkage analysis was based on 59 families from northern Sweden, consisting of a total of 129 cases of type 2 diabetes and 19 individuals with impaired glucose tolerance. Model-free linkage analysis revealed a maximum multipoint logarithm of odds score of 3.19 for D2S2987 at 267.7 cM (P = 0.00058), suggesting that a gene conferring susceptibility to type 2 diabetes in the northern Swedish population resides in the 2q37 region. These data replicate, in a European population, previously identified linkage of marker loci in this region to type 2 diabetes in Mexican Americans. In contrast, no evidence in support of association to the previously identified single nucleotide polymorphisms in the calpain-10 gene was observed in a case-control cohort derived from the same population.


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Copyright © 2006 by the American Diabetes Association.