Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Diabetes 55:1923-1929, 2006
DOI: 10.2337/db06-0151
© 2006 by the American Diabetes Association
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zelent, D.
Right arrow Articles by Matschinsky, F. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zelent, D.
Right arrow Articles by Matschinsky, F. M.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

A Glucose Sensor Role for Glucokinase in Anterior Pituitary Cells

Dorothy Zelent1, Maria L. Golson1, Brigitte Koeberlein1, Roel Quintens2, Leentje van Lommel2, Carol Buettger1, Heather Weik-Collins1, Rebecca Taub3, Joseph Grimsby3, Frans Schuit2, Klaus H. Kaestner1, and Franz M. Matschinsky1

1 University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
2 Katholieke University of Leuven, Leuven, Belgium
3 Division of Metabolic Diseases, Hoffmann La Roche, Nutley, New Jersey

Address correspondence and reprint requests to Franz M. Matschinsky, University of Pennsylvania School of Medicine, BiochemistryBiophysics, 501 Stemmler Hall, 36th & Hamilton Walk, Philadelphia, PA 19104. E-mail: matsch{at}pobox.upenn.edu

Abbreviations: GKA, glucokinase activator; GST, glutathione S-transferase; POMC, proopiomelanocortin

Enzymatic activity of glucokinase was demonstrated, quantitated, and characterized kinetically in rat and mouse pituitary extracts using a highly specific and sensitive spectrometric assay. A previously proposed hypothesis that the glucokinase gene might be expressed in the pituitary corticotrophic cells was therefore reexamined using mRNA in situ hybridization and immunohistochemical techniques. No evidence was found that corticotrophs are glucokinase positive, and the identity of glucokinase-expressing cells remains to be determined. The findings do, however, suggest a novel hypothesis that a critical subgroup of anterior pituitary cells might function as glucose sensor cells and that direct fuel regulation of such cells may modify the classical indirect neuroendocrine pathways that are known to control hormone secretion from anterior pituitary cells.


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 DiabetesHome page
B. E. Levin, T. C. Becker, J.-i. Eiki, B. B. Zhang, and A. A. Dunn-Meynell
Ventromedial Hypothalamic Glucokinase Is an Important Mediator of the Counterregulatory Response to Insulin-Induced Hypoglycemia
Diabetes, May 1, 2008; 57(5): 1371 - 1379.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
C. Crane, N. Akhter, B. W. Johnson, M. Iruthayanathan, F. Syed, A. Kudo, Y.-H. Zhou, and G. V. Childs
Fasting and Glucose Effects on Pituitary Leptin Expression: Is Leptin a Local Signal for Nutrient Status?
J. Histochem. Cytochem., October 1, 2007; 55(10): 1059 - 1073.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
C. Arden, A. Trainer, N. de la Iglesia, K. T. Scougall, A. L. Gloyn, A. J. Lange, J. A.M. Shaw, F. M. Matschinsky, and L. Agius
Cell Biology Assessment of Glucokinase Mutations V62M and G72R in Pancreatic {beta}-Cells: Evidence for Cellular Instability of Catalytic Activity
Diabetes, July 1, 2007; 56(7): 1773 - 1782.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
R. L. Sorenson, L. E. Stout, T. C. Brelje, T. L. Jetton, and F. M. Matschinsky
Immunohistochemical Evidence for the Presence of Glucokinase in the Gonadotropes and Thyrotropes of the Anterior Pituitary Gland of Rat and Monkey
J. Histochem. Cytochem., June 1, 2007; 55(6): 555 - 566.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
D. Johnson, R. M. Shepherd, D. Gill, T. Gorman, D. M. Smith, and M. J. Dunne
Glucose-Dependent Modulation of Insulin Secretion and Intracellular Calcium Ions by GKA50, a Glucokinase Activator
Diabetes, June 1, 2007; 56(6): 1694 - 1702.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. F. Pino, K.-A. Kim, K. D. Shelton, J. Lindner, S. Odili, C. Li, H. W. Collins, M. Shiota, F. M. Matschinsky, and M. A. Magnuson
Glucokinase Thermolability and Hepatic Regulatory Protein Binding Are Essential Factors for Predicting the Blood Glucose Phenotype of Missense Mutations
J. Biol. Chem., May 4, 2007; 282(18): 13906 - 13916.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2006 by the American Diabetes Association.