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Diabetes 55:2021-2024, 2006
DOI: 10.2337/db06-0063
© 2006 by the American Diabetes Association
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Plasma Interleukin-6 Levels Are Independently Associated With Insulin Secretion in a Cohort of Italian-Caucasian Nondiabetic Subjects

Francesco Andreozzi1, Emanuela Laratta1, Marina Cardellini2, Maria A. Marini2, Renato Lauro2, Marta L. Hribal1, Francesco Perticone1, and Giorgio Sesti1

1 Department of Experimental and Clinical Medicine, University Magna Græcia of Catanzaro, Catanzaro, Italy
2 Department of Internal Medicine, University of Rome-Tor Vergata, Rome, Italy

Address correspondence and reprint requests to Giorgio Sesti, MD, Dipartimento di Medicina Sperimentale e Clinica, Policlinico Mater Domini-Via Tommaso Campanella 88100, Catanzaro, Italy. E-mail: sesti{at}unicz.it

Abbreviations: AIR, acute insulin response; FFA, free fatty acid; IL-6, interleukin-6; RIAD, Risk Factors in Impaired Glucose Tolerance for Atherosclerosis and Diabetes

We have investigated the relationships between plasma interleukin-6 (IL-6) levels and insulin sensitivity and insulin secretion in a cohort of Italian-Caucasian glucose-tolerant subjects. Insulin sensitivity was assessed by euglycemic-hyperinsulinemic clamp, and first-phase insulin secretion was measured by intravenous glucose tolerance test. Fasting plasma IL-6 concentration was negatively correlated with the rate of insulin-stimulated glucose disposal (M) (P = 0.001). The correlation remained statistically significant, while attenuated, after adjusting for sex, age, and BMI (P < 0.03); after an additional adjustment for free fatty acids (FFAs), a further attenuation was observed, but statistical significance was maintained (P < 0.044). Fasting plasma IL-6 concentration was positively correlated with first-phase insulin secretion assessed as acute insulin response (AIR) (P = 0.001). The correlation remained significant after adjusting for sex, age, and BMI (P = 0.003). To estimate the independent contribution of plasma IL-6 levels to AIR, we carried out forward stepwise linear regression analysis in a model that included sex, age, BMI, waist-to-hip ratio, FFAs, and insulin-stimulated glucose disposal. Only insulin sensitivity and plasma IL-6 concentration were independently associated with AIR, accounting, respectively, for 19.0 and 5.2% of its variation. These data indicate that IL-6 is associated in a reciprocal manner with the two pathophysiological components of type 2 diabetes, i.e., insulin resistance and insulin secretion.


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Copyright © 2006 by the American Diabetes Association.