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Diabetes 55:S5-S8, 2006
DOI: 10.2337/db06-S001
© 2006 by the American Diabetes Association
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Introduction

Control of Metabolism and Growth Through Insulin-Like Peptides in Drosophila

Charles Géminard, Nathalie Arquier, Sophie Layalle, Marc Bourouis, Maija Slaidina, Renald Delanoue, Marianne Bjordal, Mickael Ohanna, May Ma, Julien Colombani, and Pierre Léopold

From the Centre National de la Recherche Scientifique/University of Nice-Sophia Antipolis, Unité Mixte de Recherche 6543, Nice, France

Address correspondence and reprint requests to Pierre Léopold, CNRS/University of Nice-Sophia Antipolis, UMR 6543, Parc Valrose, 06108 Nice cedex 2, France. E-mail: leopold{at}unice.fr

Abbreviations: 20E, 20-hydroxyecdysone; ALS, acid labile subunit; APC, AKH-producing cell; AKH, adipokinetic hormone; FB, fat body; IIS, insulin/IGF system; IPC, insulin-producing cell; IRS, insulin receptor substrate; JH, juvenile hormone; PI, phosphatidylinositol; TOR, target of rapamycin

Insulin signaling is a conserved feature in all metazoans. It evolved with the appearance of multicellularity, allowing primordial metazoans to respond to a greater diversity of environmental signals. The insulin signaling pathway is highly conserved in insects and particularly in Drosophila, where it has been extensively studied in recent years and shown to control metabolism, growth, reproduction, and longevity. Because misregulation of the insulin/IGF pathway in humans plays a role in many medical disorders, such as diabetes and various types of cancer, unraveling the regulation of insulin/IGF signaling using the power of a genetically tractable organism like Drosophila may contribute to the amelioration of these major human pathologies.


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Copyright © 2006 by the American Diabetes Association.