HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lehman, D. M. Articles by Stern, M. P. Search for Related Content PubMed PubMed Citation Articles by Lehman, D. M. Articles by Stern, M. P. Social Bookmarking                What's this?

P2 Promoter Variants of the Hepatocyte Nuclear Factor 4 Gene Are Associated With Type 2 Diabetes in Mexican Americans

¹ Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas
² Diabetes Division, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas
³ Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas
⁴ Departments of Cellular and Structural Biology and Pediatrics, University of Texas Health Science Center, San Antonio, Texas
⁵ Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas

Address correspondence and reprint requests to Donna M. Lehman, Department of Medicine/Clinical Epidemiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229. E-mail: lehman{at}uthscsa.edu

Abbreviations: LD, linkage disequilibrium; SAFDGS, San Antonio Family Diabetes and Gallbladder Studies; SNP, single nucleotide polymorphism

Common and rare variants of the hepatocyte nuclear factor 4 (HNF4A) gene have been associated with type 2 diabetes and related traits in several populations suggesting the involvement of this transcription factor in diabetes pathogenesis. Single nucleotide polymorphisms (SNPs) within a large haplotype block surrounding the alternate P2 promoter, located 45 kb upstream from the coding region, have been investigated in several populations of varying ethnicity with inconsistent results. Additionally, SNPs located within the P1 promoter and coding region have also been inconsistently associated with type 2 diabetes. Characterization of variation across this gene region in Mexican-American populations has not been reported. We therefore examined polymorphisms across the HNF4A gene in a cohort of Mexican-American pedigrees and assessed their association with type 2 diabetes. We observed evidence for association of SNPs in the P2 promoter region with type 2 diabetes (P = 0.003) and its age at diagnosis (P = 0.003). The risk allele frequency (53%) was intermediate to that reported in Caucasian populations (20–27%) and Pima Indians (83%). No other SNPs were associated with either trait. These results support the possibility that a variant in the P2 promoter region of HNF4A, or variants in linkage disequilibrium within this region, contributes to susceptibility to type 2 diabetes in many ethnic populations including Mexican Americans.

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				I. Barroso, J. Luan, E. Wheeler, P. Whittaker, J. Wasson, E. Zeggini, M. N. Weedon, S. Hunt, R. Venkatesh, T. M. Frayling, et al. Population-Specific Risk of Type 2 Diabetes Conferred by HNF4A P2 Promoter Variants: A Lesson for Replication Studies Diabetes, November 1, 2008; 57(11): 3161 - 3165. [Abstract] [Full Text] [PDF]

				S. Johansson, H. Raeder, S. A Eide, K. Midthjell, K. Hveem, O. Sovik, A. Molven, and P. R. Njolstad Studies in 3,523 Norwegians and Meta-Analysis in 11,571 Subjects Indicate That Variants in the Hepatocyte Nuclear Factor 4{alpha} (HNF4A) P2 Region Are Associated With Type 2 Diabetes in Scandinavians Diabetes, December 1, 2007; 56(12): 3112 - 3117. [Abstract] [Full Text] [PDF]