HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: db06-1656v1 56/4/1010    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fontana, L. Articles by Klein, S. Search for Related Content PubMed PubMed Citation Articles by Fontana, L. Articles by Klein, S. Social Bookmarking                What's this?

Visceral Fat Adipokine Secretion Is Associated With Systemic Inflammation in Obese Humans

¹ Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri
² Division of Food Science, Human Nutrition, and Health, Istituto Superiore di Sanitá, Rome, Italy
³ Department of Cell Biology, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York
⁴ Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York

Address correspondence and reprint requests to Samuel Klein, MD, Washington University School of Medicine, Campus Box 8031, 660 South Euclid Ave., St. Louis, MO 63110. E-mail: sklein{at}im.wustl.edu

Abbreviations: CRP, C-reactive protein; IL, interleukin; FFA, free fatty acid; HMW, high molecular weight; LMW, low molecular weight; MCP-1, macrophage chemoattractant protein-1; TNF-, tumor necrosis factor-

Although excess visceral fat is associated with noninfectious inflammation, it is not clear whether visceral fat is simply associated with or actually causes metabolic disease in humans. To evaluate the hypothesis that visceral fat promotes systemic inflammation by secreting inflammatory adipokines into the portal circulation that drains visceral fat, we determined adipokine arteriovenous concentration differences across visceral fat, by obtaining portal vein and radial artery blood samples, in 25 extremely obese subjects (mean ± SD BMI 54.7 ± 12.6 kg/m²) during gastric bypass surgery at Barnes-Jewish Hospital in St. Louis, Missouri. Mean plasma interleukin (IL)-6 concentration was 50% greater in the portal vein than in the radial artery in obese subjects (P = 0.007). Portal vein IL-6 concentration correlated directly with systemic C-reactive protein concentrations (r = 0.544, P = 0.005). Mean plasma leptin concentration was 20% lower in the portal vein than in the radial artery in obese subjects (P = 0.0002). Plasma tumor necrosis factor-, resistin, macrophage chemoattractant protein-1, and adiponectin concentrations were similar in the portal vein and radial artery in obese subjects. These data suggest that visceral fat is an important site for IL-6 secretion and provide a potential mechanistic link between visceral fat and systemic inflammation in people with abdominal obesity.

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M. Li, D. H. Kim, P. L. Tsenovoy, S. J. Peterson, R. Rezzani, L. F. Rodella, W. S. Aronow, S. Ikehara, and N. G. Abraham Treatment of Obese Diabetic Mice With a Heme Oxygenase Inducer Reduces Visceral and Subcutaneous Adiposity, Increases Adiponectin Levels, and Improves Insulin Sensitivity and Glucose Tolerance Diabetes, June 1, 2008; 57(6): 1526 - 1535. [Abstract] [Full Text] [PDF]

				T. You, W. E. Sonntag, X. Leng, and C. S. Carter Lifelong Caloric Restriction and Interleukin-6 Secretion From Adipose Tissue: Effects on Physical Performance Decline in Aged Rats J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2007; 62(10): 1082 - 1087. [Abstract] [Full Text] [PDF]

				K. M. Pou, J. M. Massaro, U. Hoffmann, R. S. Vasan, P. Maurovich-Horvat, M. G. Larson, J. F. Keaney Jr, J. B. Meigs, I. Lipinska, S. Kathiresan, et al. Visceral and Subcutaneous Adipose Tissue Volumes Are Cross-Sectionally Related to Markers of Inflammation and Oxidative Stress: The Framingham Heart Study Circulation, September 11, 2007; 116(11): 1234 - 1241. [Abstract] [Full Text] [PDF]

				W. Jia, H. Wu, Y. Bao, C. Wang, J. Lu, J. Zhu, and K. Xiang Association of Serum Retinol-Binding Protein 4 and Visceral Adiposity in Chinese Subjects with and without Type 2 Diabetes J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 3224 - 3229. [Abstract] [Full Text] [PDF]

				G. Murdolo, A. Hammarstedt, M. Sandqvist, M. Schmelz, C. Herder, U. Smith, and P.-A. Jansson Monocyte Chemoattractant Protein-1 in Subcutaneous Abdominal Adipose Tissue: Characterization of Interstitial Concentration and Regulation of Gene Expression by Insulin J. Clin. Endocrinol. Metab., July 1, 2007; 92(7): 2688 - 2695. [Abstract] [Full Text] [PDF]

				M. Qatanani and M. A. Lazar Mechanisms of obesity-associated insulin resistance: many choices on the menu Genes & Dev., June 15, 2007; 21(12): 1443 - 1455. [Abstract] [Full Text] [PDF]