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Genetic Similarities Between Latent Autoimmune Diabetes in Adults, Type 1 Diabetes, and Type 2 Diabetes

¹ Department of Clinical Sciences—Diabetes & Endocrinology, Clinical Research Center, Malmö University Hospital, Lund University, Malmö, Sweden
² Department of Medicine, Malmö University Hospital, Lund University, Malmö, Sweden
³ Department of Medicine, Helsinki University Central Hospital, and Research Program of Molecular Medicine, University of Helsinki, Helsinki, Finland
⁴ Folkhalsan Research Centre, Helsinki, Finland
⁵ Department of Clinical Sciences, Cellular Autoimmunity Unit, Clinical Research Center, Malmö University Hospital, Lund University, Malmö, Sweden

Corresponding author: Leif Groop, Department of Clinical Sciences—Diabetes & Endocrinology, Clinical Research Center, Malmö University Hospital, Lund University, S-205 02 Malmö, Sweden. E-mail: leif.groop{at}med.lu.se

Abbreviations: GADA, GAD autoantibody; LADA, latent autoimmune diabetes in adults

OBJECTIVE—Latent autoimmune diabetes in adults (LADA) is often considered a slowly progressing subtype of type 1 diabetes, although the clinical picture more resembles type 2 diabetes. One way to improve classification is to study whether LADA shares genetic features with type 1 and/or type 2 diabetes.

RESEARCH DESIGN AND METHODS—To accomplish this, we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA, 718 type 1 diabetic, and 1,676 type 2 diabetic patients, as well as 1,704 healthy control subjects from Sweden and Finland.

RESULTS—LADA subjects showed, compared with type 2 diabetic patients, increased frequency of risk for the HLA-DQB1 *0201/*0302 genotype (27 vs. 6.9%; P < 1 x 10^–6), with similar frequency as with type 1 diabetes (36%). In addition, LADA subjects showed higher frequencies of protective HLA-DQB1 *0602(3)/X than type 1 diabetic patients (8.1 vs. 3.2%, P = 0.003). The AA genotype of rs689, referring to the class I allele in the INS VNTR, as well as the CT/TT genotypes of rs2476601 in the PTPN22 gene, were increased both in type 1 diabetic (P = 3 x 10^–14 and P = 1 x 10^–10, respectively) and LADA (P = 0.001 and P = 0.002) subjects compared with control subjects. Notably, the frequency of the type 2 diabetes–associated CT/TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects (52.8%; P = 0.03), to the same extent as in type 2 diabetic subjects (54.1%, P = 3 x 10^–7), compared with control subjects (44.8%) and type 1 diabetic subjects (43.3%).

CONCLUSIONS—LADA shares genetic features with both type 1 (HLA, INS VNTR, and PTPN22) and type 2 (TCF7L2) diabetes, which justifies considering LADA as an admixture of the two major types of diabetes.

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Genetic Similarities Between Latent Autoimmune Diabetes and Type 1 and Type 2 Diabetes

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				A. K. Steck and G. S. Eisenbarth Genetic Similarities Between Latent Autoimmune Diabetes and Type 1 and Type 2 Diabetes Diabetes, May 1, 2008; 57(5): 1160 - 1162. [Full Text] [PDF]