HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Henquin, J.-C. Articles by Cerasi, E. Search for Related Content PubMed PubMed Citation Articles by Henquin, J.-C. Articles by Cerasi, E. Social Bookmarking                What's this?

Insulin Secretion: Movement at All Levels

¹ Department of Physiology, Endocrinology-Metabolism, Université Catholique de Louvain, Brussels, Belgium
² INSERM U342, St. Vincent de Paul Hospital, Paris, France
³ Department of Molecular Medicine, Division of Endocrinology & Diabetes, Karolinska Hospital, Stockholm, Sweden
⁴ Metabolism Unit, CNR Institute of Clinical Physiology, University of Pisa, Pisa, Italy
⁵ Department of Biochemistry and Molecular Biology and Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois
⁶ Department of Endocrinology & Metabolism, Hebrew University Hadassah Medical Center, Jerusalem, Israel

With this Second SERVIER-IGIS Symposium Diabetes Supplement, we, the members of the International Group on Insulin Secretion (IGIS), happily realize that we have been able to keep the promise made in the First SERVIER-IGIS Symposium (Diabetes 50 [Suppl. 1], 2001): we are indeed initiating a tradition, with a yearly series of state-of-the-art collections on various aspects of islet biology, with the emphasis on type 2 diabetes. Without the logistics and the generous unrestricted educational grant put at our disposal by SERVIER, Paris, it is doubtful that we would ever embark on this project, let alone succeed in producing these high-quality publications.

The Second SERVIER-IGIS Symposium dealt with the "Kinetics of Insulin Release in Health and Type 2 Diabetes." To optimally fulfill its preeminent role in glucose homeostasis, insulin secretion must not only be quantitatively appropriate, it must also follow a precise time course. It has indeed been known since the 1960s that insulin secretion is phasic; later work refined the definition of phasicity by the discovery of superimposed oscillations of varying frequencies. Many of these features are absent or disturbed in type 2 diabetic patients, sometimes before overt hyperglycemia is established. These convincing findings notwithstanding, the conditions required to demonstrate certain aspects of phasic insulin release are sometimes unphysiological. Just to mention the often used hyperglycemic clamp, in nature the ß-cell is never exposed to a "jump" of the extracellular glucose concentration from 5 to 15–20 mmol/l within 2–3 min. It is therefore a legitimate question whether phasic insulin release is a bona fide biological characteristic of the ß-cell. This supplement examines the question from several angles, at . . . [Full Text of this Article]

ACKNOWLEDGMENTS

FOOTNOTES

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				E. K. de Jong, I. M. Dijkstra, M. Hensens, N. Brouwer, M. van Amerongen, R. S. B. Liem, H. W. G. M. Boddeke, and K. Biber Vesicle-Mediated Transport and Release of CCL21 in Endangered Neurons: A Possible Explanation for Microglia Activation Remote from a Primary Lesion J. Neurosci., August 17, 2005; 25(33): 7548 - 7557. [Abstract] [Full Text] [PDF]

				A. Caumo and L. Luzi First-phase insulin secretion: does it exist in real life? Considerations on shape and function Am J Physiol Endocrinol Metab, September 1, 2004; 287(3): E371 - E385. [Abstract] [Full Text] [PDF]