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Interaction Between Exercise and Leptin in the Treatment of Obesity

From the Pennington Biomedical Research Center, Baton Rouge, Louisiana

Address correspondence and reprint requests to Christopher Morrison, Pennington Biomedical Research Center, 6400 Perkins Rd., Baton Rouge, LA 70808. E-mail: morriscd@pbrc.edu

The first 20% of the full text of this article appears below.

Recent data indicate that roughly 32% of the U.S. population is obese and an additional 34% is overweight (1). Considering the physical, psychological, and physiological complications associated with obesity, developing approaches to reduce these numbers is of critical importance. The identification of leptin as a hormonal link between energy stores and the brain inspired a renewed focus on the study of energy balance and contributed to the description of a neuronal network that mediates the metabolic regulation of feeding behavior, reproduction, glucose homeostasis, immune function, bone formation, lipid metabolism, etc. But for all its promise, much of the initial enthusiasm over leptin has waned with the realization that obese individuals respond rather poorly to leptin treatment and manifest a syndrome of leptin resistance. Although leptin may not be the anti-obesity treatment initially hoped for, there may yet be life to the leptin story. Just as progress has been made in defining and overcoming insulin resistance, considerable effort has focused on developing approaches to overcome leptin resistance. In this issue of Diabetes, Shapiro et al. (2) provide evidence that modest exercise synergizes with leptin treatment to markedly reduce body weight in individuals made obese by a high-fat diet, even though neither reduce body weight . . . [Full Text of this Article]

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