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Response to Comment on: Kretowski et al. (2007) Polymorphisms of the Renin-Angiotensin System Genes Predict Progression of Subclinical Coronary Atherosclerosis: Diabetes 56:863–871

¹ Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado
² Department of Endocrinology, Diabetology, and Internal Medicine, Medical University of Bialystok, Bialystok, Poland

Address correspondence to Adam Kretowski, University of Colorado at Denver and Health Sciences Center–Barbara Davis Center for Childhood Diabetes, 1775 N. Ursula St., Mail Stop A140, P.O. Box 6511, Aurora, CO 80045-6511. E-mail: kretowski{at}uchsc.edu

We totally agree with van Beers and Meuwese (1) that our study strongly supports the association of angiotensinogen (AGT) M235T polymorphism with coronary artery calcification (CAC) progression in subjects with type 1 diabetes. However, we also believe that the additive effect of ACE and/or angiotensin type 1 receptor (ATR1) genes on CAC progression is supported by data included in our study (2).

In the logistic regression analysis among subjects with type 1 diabetes, AGT TT genotype and ATR1 AA+AC genotypes, but not ACE ID genotype, independently predicted CAC progression. When the interaction between AGT TT and ACE ID genotypes had been added to the model, this interaction was found to have a significant effect on CAC progression (OR_{AGT TT x ACE ID} = 3.6, P = 0.037), with the suggestive deviance of two studied models (² = 4.094, P = 0.043). Unfortunately, we were unable to perform a test of the two-way interaction between AGT TT and ATR1 AA/AC or a test of three-way interaction due to complete separation of the data.

However, the additive effect of the AGT-ATR1 genotype combinations on the frequencies of CAC progression is supported by data in Table 4 of our study (2). CAC progression was significantly higher among subjects with the suggested AGT-ATR1 genotype combinations [TT- AA+AC vs. TT-CC: 39.5% (15/38) vs. 0.0% (0/8), P = 0.039, Fisher's exact test] among subjects without hypertension/albuminuria and those with albuminuria/hypertension but not treated with ACE/ARB during the follow up.

Received for publication March 23, 2007 and accepted in revised form March 24, 2007

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1. van Beers EJ, Meuwese MC: Comment on: Kretowski et al. (2007) Polymorphisms of the renin-angiotensin system genes predict progression of subclinical coronary atherosclerosis: Diabetes 56:863–871. Diabetes 56:e5, 2007. DOI: 10.2337/db07-0400[Abstract/Free Full Text]
2. Kretowski A, McFann K, Hokanson JE, Maahs D, Kinney G, Snell-Bergeon JK, Wadwa RP, Eckel RH, Ogden L, Garg S, Li J, Cheng S, Erlich HA, Rewers M: Polymorphisms of the renin-angiotensin system genes predict progression of subclinical coronary atherosclerosis. Diabetes 56:863–871, 2007[Abstract/Free Full Text]

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This Article Extract Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kretowski, A. Articles by Rewers, M. Search for Related Content PubMed Articles by Kretowski, A. Articles by Rewers, M. Social Bookmarking                What's this?