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Diabetes 57:e10 2008
DOI: 10.2337/db08-0173
© 2008 by the American Diabetes Association
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Online Letters to the Editor

Comment on: DiChiara et al. (2007) The Effect of Aspirin Dosing on Platelet Function in Diabetic and Nondiabetic Patients: An Analysis From the Aspirin-Induced Platelet Effect (ASPECT) Study: Diabetes 56:3014–3019, 2007

Petra-Susanne Klein

From the Universitetssykehuset Nord-Norge, Avdeling for Fysikalsk Medisin og Rehabilitering, Tromsø, Norway

Corresponding author: Petra-Susanne Klein, Universitetssykehuset Nord-Norge, Avdeling for Fysikalsk Medisin og, Rehabilitering, Postboks 100, Tromsø 9038, Norway. E-mail: petra-susanne.klein{at}unn.no

I read with interest the recently published study (1) comparing antiplatelet potency of three aspirin doses in the diabetic and nondiabetic cohorts of the Aspirin-Induced Platelet Effect (ASPECT) trial. The study represents a post hoc analysis of the original ASPECT study published elsewhere (2). The attempts of the authors to exploit the original database by further analyses are valuable, especially when an important clinical message cannot fit within the framework of the main article. However, the reporting of baseline data in these two ASPECT publications raises concerns and deserves further scrutiny. Indeed, most of the numbers presented in Table 1 for both publications do not match. The differences are outlined in Table 1 of this letter.


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  		TABLE 1 Baseline data

 
Surprisingly, the only matched variables for both studies were age, weight, and the number of diabetic subjects. After attempts to perform comprehensive statistical analyses, taking into account the complicated crossover design of ASPECT provided in the original article (1), it is not possible to gain an understanding of the true database. In fact, such discrepancies may challenge not only the quality of the second analysis published in Diabetes but also the primary ASPECT report.

Received for publication February 7, 2008 and accepted in revised form February 7, 2008


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  1. DiChiara J, Bliden KP, Tantry US, Hamed MS, Antonino MJ, Suarez TA, Bailon O, Singla A, Gurbel PA: The effect of aspirin dosing on platelet function in diabetic and nondiabetic patients: an analysis from the Aspirin-Induced Platelet Effect (ASPECT) study. Diabetes 56:3014–3019, 2007[Abstract/Free Full Text]
  2. Gurbel PA, Bliden KP, Dichiara J, Newcomer J, Weng W, Neerchal NK, Gesheff T, Chaganti SK, Etherington A, Tantry US: Evaluation of dose-related effects of aspirin on platelet function: results from the Aspirin-Induced Platelet Effect (ASPECT) study. Circulation 115:3156–3164, 2007[Abstract/Free Full Text]

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J. DiChiara, K. P. Bliden, U. S. Tantry, M. S. Hamed, M. J. Antonino, T. A. Suarez, O. Bailon, A. Singla, and P. A. Gurbel
Response to Comment on: DiChiara et al. (2007) The Effect of Aspirin Dosing on Platelet Function in Diabetic and Nondiabetic Patients: An Analysis From the Aspirin-Induced Platelet Effect (ASPECT) Study: Diabetes 56:3014-3019, 2007
Diabetes, May 1, 2008; 57(5): e11 - e11.
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