Online-Only Appendix

Files in this Data Supplement:

• Supplemental FIG. 1. AMPK activation induces AMPK phosphorylation and represses hepatic gluconeogenic gene expression via SHP.
• Supplemental FIG. 2. Metformin inhibits the promoter activities and gene expression of hepatic gluconeogenic genes.
• Supplemental FIG. 3. Downregulations of PEPCK and G6Pase gene expression by metformin are mediated via SHP.
• Supplemental FIG. 4. Metformin increases the phosphorylation of ACC and AMPK in liver of B6-Lepob/ob mice in a dose-dependent manner.
• Supplemental Figure Legends