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Diabetes Publish Ahead of Print published online ahead of print May 22, 2003
DOI: 10.2337/diabetes.52.7.1591

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Received for publication 27 December 2002
Accepted in revised form 28 April 2003

Magnetic Resonance-Defined Periportal Steatosis Following Intraportal Islet Transplantation. A Functional Footprint of Islet Graft Survival?

James F. Markmann 1 *, Mark Rosen 2 , Evan S. Siegelman 2 , Michael C. Soulen 2 , Shaoping Deng 1 , Clyde F. Barker 1 , and Ali Naji 1

From the 1 Department of Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania and 2 Department of Radiology, University of Pennsylvania Health System, Philadelphia, Pennsylvania

* Address correspondence and reprint requests to James F. Markmann. Email: james.markmann{at}uphs.upenn.edu.

There is growing interest in more widespread application of isolated islet transplantation for the treatment of type 1 diabetes; however, the sequelae of long-term islet residence within the liver are unknown. We report herein a consequence of intraportal islet transplantation, specifically the development of periportal hepatic steatosis apparently induced by the local secretion of insulin within the liver.


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