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Published online November 14, 2007
Diabetes 57:623-626, 2008
DOI: 10.2337/db07-0408
© 2008 by the American Diabetes Association
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Brief Report

Evidence of an Influence of a Polymorphism Near the INSIG2 on Weight Loss During a Lifestyle Intervention in Obese Children and Adolescents

Thomas Reinehr1, Anke Hinney2, Thuy Trang Nguyen3, and Johannes Hebebrand2

1 Vestische Hospital for Children and Adolescents, University of Witten/Herdecke, Witten, Datteln, Germany
2 Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Essen, Germany
3 Institute of Medical Biometry and Epidemiology, Philipps-University of Marburg, Marburg, Germany

Address correspondence and reprint requests to Dr. T. Reinehr, Vestische Hospital for Children and Adolescents, University of Witten/Herdecke, Dr. F. Steiner Str. 5, 45711 Datteln, Germany. E-mail: t.reinehr{at}kinderklinik-datteln.de

Key Words: HOMA, homeostasis model assessment • SDS, SD score • SNP, single nucleotide polymorphism

OBJECTIVE—Homozygotes for the C-allele of the single nucleotide polymorphism (SNP) rs7566605, located ~10 kb upstream of insulin-induced gene 2 (INSIG2), showed a slightly increased risk of becoming obese. The aim of this study was to analyze whether children homozygous for the C-allele lose less weight in an intervention than children with the GG- or GC-genotype.

RESEARCH DESIGN AND METHODS—We genotyped rs7566605 in 293 obese children (mean age 10.8 years, 45% male, mean BMI 28.1 kg/m2) who presented for a 1-year intervention. The reduction of SD score (SDS) BMI was compared based on an intention-to-treat analysis between the children with different genotypes. Blood pressure, triglycerides, insulin and glucose concentrations, and total, HDL, and LDL cholesterol were measured before and after intervention.

RESULTS—After 1 year, obese children with the CC-genotype had reduced their SDS BMI to a lower extent than obese children with GC- or GG-genotypes (recessive model P = 0.007). There was no evidence for an association of rs7566605 with the cardiovascular risk factor profile (nominal P > 0.1).

CONCLUSIONS—CC-homozygotes at SNP rs7566605 in the vicinity of INSIG2 lost less weight in this lifestyle intervention. This finding further implicates this polymorphism in weight regulation.


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