Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Diabetes Publish Ahead of Print published online ahead of print April 19, 2007
DOI: 10.2337/db06-1127
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
db06-1127v1
56/7/1905    most recent
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yazdanpanah, M
Right arrow Articles by van Duijn, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yazdanpanah, M
Right arrow Articles by van Duijn, C.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Original Research

Effects of the renin-angiotensin system genes and salt sensitivity genes on blood pressure and atherosclerosis in the total population and patients with type 2 diabetes

M Yazdanpanah, MD, PhD1, YS Aulchenko, PhD1, A Hofman, MD, PhD1, JAMJL Janssen, MD, PhD2, FA Sayed-Tabatabaei, MD, PhD1, RHN van Schaik, PhD3, OH Klungel, PhD4, BHCh Stricker, PhD1, HAP Pols, MD, PhD1,,2, JCM Witteman, PhD1, SWJ Lamberts, MD, PhD2, BA Oostra, PhD1, and CM van Duijn, PhD1

1Genetic Epidemiology Unit: Department of Epidemiology & Biostatistics and Department of Clinical Genetics
2Department of Internal Medicine
3Department of Clinical Chemistry, Erasmus Medical Centre, Rotterdam, The Netherlands
4Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, The Netherlands

Correspondence: c.vanduijn{at}erasmusmc.nl

Key Words: angiotensinogen • angiotensin II receptor 1 • angiotensin converting enzyme • alpha-adducin • G-protein • cytochrome P-450 • blood pressure • atherosclerosis • type 2 diabetes

Most studies on the genetic determinants of blood pressure and vascular complications of type 2 diabetes have studied the effects of single genes. These studies have often yielded conflicting results. Therefore, we examined the combined effects of three renin-angiotensin system (RAS) genes and three salt sensitivity genes in relation to blood pressure and atherosclerosis in the total population and type 2 diabetic patients.

The study was a part of Rotterdam Study, a population-based cohort study. We have genotyped three RAS gene polymorphisms, and three salt sensitivity gene polymorphisms. Diabetic patients with three risk genotypes of the RAS genes had a 6.9 mmHg higher systolic blood pressure (p for trend = 0.04) and a 6.0 mmHg higher pulse pressure (p for trend = 0.03) than those who did not carry any risk genotypes. Diabetic patients with three risk genotypes of the salt sensitivity genes had a 9.0 mmHg higher systolic blood pressure (p = 0.19) and a 13.1 mmHg higher pulse pressure (p = 0.02). Diabetic patients who carried three risk genotypes for the RAS genes had a higher mean intima media thickness than those with two risk genotypes (mean difference = 0.04 mm, p = 0.02).

We found that among type 2 diabetic patients mean systolic blood pressure, pulse pressure and risk of hypertension increased with the number of risk genotypes for the RAS genes and the salt sensitivity genes.


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2007 by the American Diabetes Association.